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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2011-5-27
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pubmed:abstractText |
Insulin resistance is associated with elevated content of skeletal muscle lipids, including triacylglycerols (TAGs) and diacylglycerols (DAGs). DAGs are by-products of lipolysis consecutive to TAG hydrolysis by adipose triglyceride lipase (ATGL) and are subsequently hydrolyzed by hormone-sensitive lipase (HSL). We hypothesized that an imbalance of ATGL relative to HSL (expression or activity) may contribute to DAG accumulation and insulin resistance.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1939-327X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1734-42
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pubmed:meshHeading |
pubmed-meshheading:21498783-Adult,
pubmed-meshheading:21498783-Chromatography, Gas,
pubmed-meshheading:21498783-Diglycerides,
pubmed-meshheading:21498783-Female,
pubmed-meshheading:21498783-Glucose Clamp Technique,
pubmed-meshheading:21498783-Humans,
pubmed-meshheading:21498783-Insulin Resistance,
pubmed-meshheading:21498783-Lipase,
pubmed-meshheading:21498783-Male,
pubmed-meshheading:21498783-Mass Spectrometry,
pubmed-meshheading:21498783-Middle Aged,
pubmed-meshheading:21498783-Muscle, Skeletal,
pubmed-meshheading:21498783-Spectrometry, Mass, Electrospray Ionization,
pubmed-meshheading:21498783-Sterol Esterase,
pubmed-meshheading:21498783-Tandem Mass Spectrometry,
pubmed-meshheading:21498783-Triglycerides,
pubmed-meshheading:21498783-Young Adult
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pubmed:year |
2011
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pubmed:articleTitle |
Altered skeletal muscle lipase expression and activity contribute to insulin resistance in humans.
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pubmed:affiliation |
INSERM, U1048, Obesity Research Laboratory, Institute of Metabolicand Cardiovascular Diseases (I2MC), Toulouse, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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