Linked Life Data

21496867

Source:http://linkedlifedata.com/resource/pubmed/id/21496867

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2011-9-29
pubmed:abstractText
Disabled-2 expression is reduced in many cancers, suggesting that it is a potential tumor suppressor protein. To elucidate the role of Disabled-2 in lung cancer, we examined the expression of Disabled-2, the Disabled-2-binding protein Axin, and DNA methyltransferase-1 in lung cancer tissues and corresponding normal lung tissues using immunohistochemistry and Western blots. We also determined the subcellular localization of Axin and Disabled-2 in A549 cells using confocal immunofluorescence. Disabled-2 expression was significantly reduced in lung cancers and was colocalized and coexpressed with Axin (correlation coefficient = 0.321, P < .001 for cytoplasmic expression; correlation coefficient = 0.393, P < .001 for nuclear expression). Reduced nuclear Disabled-2 expression was correlated with the differentiation (P = .048) and TNM stage (P = .048) of the tumor. The cytoplasmic expression of Axin was also correlated with differentiation (P = .042), whereas the nuclear expression of Axin was correlated with both histologic type (P = .001) and TNM stage (P < .001) of lung cancers. Expression of DNA methyltransferase-1 was negatively correlated with the cytoplasmic expression of Axin (correlation coefficient = -0.244, P = .012) but positively correlated with the histologic type (P = .004), differentiation (P = .036), TNM stage (P = .044), and lymphatic metastasis (P = .011). Expressions of Disabled-2 and Axin were concurrently reduced and correlated with the malignant phenotype of lung cancers. Enhanced expression of DNA methyltransferase-1 correlated with the reduced expression of Axin and could be a marker for lung cancer development and progression.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1532-8392
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1491-8
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:21496867-Adaptor Proteins, Signal Transducing, pubmed-meshheading:21496867-Adenocarcinoma, pubmed-meshheading:21496867-Adult, pubmed-meshheading:21496867-Aged, pubmed-meshheading:21496867-Aged, 80 and over, pubmed-meshheading:21496867-Axin Protein, pubmed-meshheading:21496867-Carcinoma, Squamous Cell, pubmed-meshheading:21496867-Cell Nucleus, pubmed-meshheading:21496867-Cytoplasm, pubmed-meshheading:21496867-DNA (Cytosine-5-)-Methyltransferase, pubmed-meshheading:21496867-Female, pubmed-meshheading:21496867-Humans, pubmed-meshheading:21496867-Lung Neoplasms, pubmed-meshheading:21496867-Lymphatic Metastasis, pubmed-meshheading:21496867-Male, pubmed-meshheading:21496867-Middle Aged, pubmed-meshheading:21496867-Repressor Proteins, pubmed-meshheading:21496867-Tumor Markers, Biological, pubmed-meshheading:21496867-Young Adult
pubmed:year
2011
pubmed:articleTitle
Disabled-2 and Axin are concurrently colocalized and underexpressed in lung cancers.
pubmed:affiliation
Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences of China Medical University, Shenyang 110001, China. xu.htao@yahoo.com.cn
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't