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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2011-5-25
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pubmed:abstractText |
Galanin is expressed at low levels in the intact sensory neurons of the dorsal root ganglia with a dramatic increase after peripheral nerve injury. The neuropeptide is also expressed in primary afferent terminals in the dorsal horn, spinal inter-neurons and in a number of brain regions known to modulate nociception. Intrathecal administration of galanin modulates sensory responses in a dose-dependent manner with inhibition at high doses. To date it is unclear which of the galanin receptors mediates the anti-nociceptive effects of the neuropeptide and whether their actions are peripherally and/or centrally mediated. In the present study we investigated the effects of direct administration into the receptive field of galanin and the galanin receptor-2/3-agonist Gal2-11 on nociceptive primary afferent mechanical responses in intact rats and mice and in the partial saphenous nerve injury (PSNI) model of neuropathic pain.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-10051743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-10215923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-10379831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-10619483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-10781925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-10864935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-11016970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-11078928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-11287480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-11481429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-12368071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-12406501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-12438940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-12605908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-12617941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-12654333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-12721371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-12842279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-1370746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-1373497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-14656291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-14984413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-15041741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-15275747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-15464755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-1574584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-15857713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-15944007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-15944015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-16436616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-16626647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-1707368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-17076662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-17170700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-17600376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-17693056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-17910903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-18463495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-18598259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-2412667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-2450311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-2450313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-2458280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-2471574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-2484006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-2484726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-3225349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-411895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-6282398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-6656869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-7511846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-7523987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-7686215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-7689499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-9051788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-9150295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-9359612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-9422803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-9453214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21496293-9462875
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1744-8069
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
26
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pubmed:meshHeading |
pubmed-meshheading:21496293-Animals,
pubmed-meshheading:21496293-Disease Models, Animal,
pubmed-meshheading:21496293-Galanin,
pubmed-meshheading:21496293-Hyperalgesia,
pubmed-meshheading:21496293-Male,
pubmed-meshheading:21496293-Mice,
pubmed-meshheading:21496293-Mice, Transgenic,
pubmed-meshheading:21496293-Nerve Fibers,
pubmed-meshheading:21496293-Nociceptors,
pubmed-meshheading:21496293-Pain,
pubmed-meshheading:21496293-Rats,
pubmed-meshheading:21496293-Rats, Wistar,
pubmed-meshheading:21496293-Receptors, Galanin
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pubmed:year |
2011
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pubmed:articleTitle |
Activation of the galanin receptor 2 in the periphery reverses nerve injury-induced allodynia.
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