21496273

Source:http://linkedlifedata.com/resource/pubmed/id/21496273

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0334227, umls-concept:C0376358, umls-concept:C0754570, umls-concept:C1510852, umls-concept:C1515655, umls-concept:C1533691
pubmed:dateCreated	2011-5-18
pubmed:abstractText	Perifosine is a membrane-targeted alkylphospholipid developed to inhibit the PI3K/Akt pathway and has been suggested as a favorable candidate for combined use with radiotherapy. In this study, we investigated the effect of the combined treatment of perifosine and radiation (CTPR) on prostate cancer cells in vitro and on prostate cancer xenografts in vivo.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-10344758, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-10462204, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-10699948, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-11173135, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-11314048, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-11466625, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-12871080, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-1316230, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-14751526, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-15168354, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-15297428, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-15450723, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-15724144, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-15781658, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-16034524, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-16103096, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-16138006, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-16140961, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-16170346, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-16514137, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-16533789, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-16722524, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-17287087, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-1846318, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-19216841, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-3037531, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-7657393, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-8620456, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-8770865, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-9155530, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-9215791, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-9547349, http://linkedlifedata.com/resource/pubmed/commentcorrection/21496273-9843996
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101265111
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Phosphorylcholine, http://linkedlifedata.com/resource/pubmed/chemical/Radiation-Sensitizing Agents
pubmed:status	MEDLINE
pubmed:issn	1748-717X
pubmed:author	pubmed-author:BrinkmanKathryn LKL, pubmed-author:ButlerE BrianEB, pubmed-author:FlorykDanielD, pubmed-author:GaoYuanhongY, pubmed-author:HuangYingY, pubmed-author:IshiyamaHiromichiH, pubmed-author:IttmannMichaelM, pubmed-author:LinN SNS, pubmed-author:MaiWeiyuanW, pubmed-author:SunMianenM, pubmed-author:TehBin SBS, pubmed-author:ThompsonTimothy CTC, pubmed-author:WangXiaozhenX, pubmed-author:ZhuJulieJ
pubmed:issnType	Electronic
pubmed:volume	6
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	39
pubmed:meshHeading	pubmed-meshheading:21496273-Animals, pubmed-meshheading:21496273-Apoptosis, pubmed-meshheading:21496273-Cell Line, Tumor, pubmed-meshheading:21496273-Cell Proliferation, pubmed-meshheading:21496273-Humans, pubmed-meshheading:21496273-Male, pubmed-meshheading:21496273-Mice, pubmed-meshheading:21496273-Mice, Nude, pubmed-meshheading:21496273-Phosphorylcholine, pubmed-meshheading:21496273-Prostatic Neoplasms, pubmed-meshheading:21496273-Radiation-Sensitizing Agents, pubmed-meshheading:21496273-Treatment Outcome
pubmed:year	2011
pubmed:articleTitle	The alkylphospholipid, perifosine, radiosensitizes prostate cancer cells both in vitro and in vivo.
pubmed:affiliation	Department of Radiation Oncology, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, TX 77030, USA.
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't