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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2011-6-10
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pubmed:abstractText |
Heat shock proteins (Hsp) are known to enhance cell survival under various stress conditions. In the heart, the small Hsp20 has emerged as a key mediator of protection against apoptosis, remodeling, and ischemia/reperfusion injury. Moreover, Hsp20 has been implicated in modulation of cardiac contractility ex vivo. The objective of this study was to determine the in vivo role of Hsp20 in the heart and the mechanisms underlying its regulatory effects in calcium (Ca) cycling.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1524-4571
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pubmed:author |
pubmed-author:CaiWenfengW,
pubmed-author:FanGuo-ChangGC,
pubmed-author:FloreaStela MSM,
pubmed-author:HaghighiKobraK,
pubmed-author:KraniasEvangelia GEG,
pubmed-author:LamChi KungCK,
pubmed-author:PritchardTracy JTJ,
pubmed-author:QianJiangJ,
pubmed-author:RodriguezPatriciaP,
pubmed-author:SanoudouDespinaD,
pubmed-author:SinghVivek PVP,
pubmed-author:SongWeizhongW,
pubmed-author:VafiadakiElizabethE,
pubmed-author:WangHong-ShengHS,
pubmed-author:WangYigangY,
pubmed-author:YuanQunyingQ
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pubmed:issnType |
Electronic
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pubmed:day |
10
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pubmed:volume |
108
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1429-38
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:21493896-Amino Acid Substitution,
pubmed-meshheading:21493896-Animals,
pubmed-meshheading:21493896-Calcium,
pubmed-meshheading:21493896-Calcium-Binding Proteins,
pubmed-meshheading:21493896-HSP20 Heat-Shock Proteins,
pubmed-meshheading:21493896-Heart Diseases,
pubmed-meshheading:21493896-Mice,
pubmed-meshheading:21493896-Mice, Transgenic,
pubmed-meshheading:21493896-Mutation, Missense,
pubmed-meshheading:21493896-Myocardial Contraction,
pubmed-meshheading:21493896-Myocardium,
pubmed-meshheading:21493896-Phosphorylation,
pubmed-meshheading:21493896-Protein Phosphatase 1,
pubmed-meshheading:21493896-Sarcoplasmic Reticulum,
pubmed-meshheading:21493896-Sarcoplasmic Reticulum Calcium-Transporting ATPases
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pubmed:year |
2011
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pubmed:articleTitle |
Small heat shock protein 20 interacts with protein phosphatase-1 and enhances sarcoplasmic reticulum calcium cycling.
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pubmed:affiliation |
Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0575, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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