Source:http://linkedlifedata.com/resource/pubmed/id/21493073
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
2011-4-28
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pubmed:abstractText |
To search for a new class of antidiabetic compounds, effects of 44 flavonoids on the adipogenesis of 3T3-L1 cells were examined. Among them, 3,4',7-trimethylkaempferol, tetramethylkaempferol, and pentamethylquercetin concentration-dependently enhanced the accumulation of triglyceride, a marker of adipogenesis. With regard to structural requirements of flavonoids for the activity, it was fond that: (1) most flavonoids having hydroxy groups lacked the effect; (2) flavonols with methoxy groups showed stronger effects particularly those with a methoxy group at the 3-position; and (3) a methoxy group of flavonols at the B ring was also important. 3,4',7-Trimethylkaempferol, tetramethylkaempferol, and pentamethylquercetin significantly increased the amount of adiponectin released into the medium and the uptake of 2-deoxyglucose into the cells. Furthermore, tetramethylkaempferol and pentamethylquercetin also increased mRNA levels of adiponectin, glucose transporter 4 (GLUT4), and fatty acid-binding protein (aP2). Both compounds also increased the mRNA levels of peroxisome proliferator-activated receptor (PPAR)?2 and CCAAT/enhancer-binding protein (C/EBP)?, ?, and/or ?, although, different from troglitazone, they did not activate PPAR? directly in a nuclear receptor cofactor assay.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CCAAT-Enhancer-Binding Protein-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/CCAAT-Enhancer-Binding Protein-beta,
http://linkedlifedata.com/resource/pubmed/chemical/CCAAT-Enhancer-Binding Protein-delta,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyglucose,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acid-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose Transporter Type 4,
http://linkedlifedata.com/resource/pubmed/chemical/PPAR gamma
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1464-3391
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pubmed:author | |
pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2835-41
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pubmed:meshHeading |
pubmed-meshheading:21493073-3T3-L1 Cells,
pubmed-meshheading:21493073-Adipogenesis,
pubmed-meshheading:21493073-Animals,
pubmed-meshheading:21493073-CCAAT-Enhancer-Binding Protein-alpha,
pubmed-meshheading:21493073-CCAAT-Enhancer-Binding Protein-beta,
pubmed-meshheading:21493073-CCAAT-Enhancer-Binding Protein-delta,
pubmed-meshheading:21493073-Deoxyglucose,
pubmed-meshheading:21493073-Fatty Acid-Binding Proteins,
pubmed-meshheading:21493073-Flavonoids,
pubmed-meshheading:21493073-Glucose Transporter Type 4,
pubmed-meshheading:21493073-Mice,
pubmed-meshheading:21493073-PPAR gamma,
pubmed-meshheading:21493073-Structure-Activity Relationship
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pubmed:year |
2011
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pubmed:articleTitle |
Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells.
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pubmed:affiliation |
Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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