Source:http://linkedlifedata.com/resource/pubmed/id/21492189
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2011-4-15
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pubmed:abstractText |
The objective of this study was to investigate the pharmacokinetics and bioavailability of valnemulin in broiler chickens after intravenous (i.v.), intramuscular (i.m.) and oral administrations of 10 mg/kg body weight (bw). Plasma samples were analyzed by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Pharmacokinetic characterization was performed by non-compartmental analysis using WinNonlin program. After intravenous administration, distribution was wide with the volume of distribution based on terminal phase(V(z)) of 4.27 ± 0.99 L?/kg. Mean valnemulin t(1/2?)(h), Cl(?)(L?/h?/kg), V(ss)(L?/kg) and AUC((0-?))(?g·h?/mL) values were 2.85, 0.99, 2.72 and 10.34, respectively. After intramuscular administration, valnemulin was rapidly absorbed with a C(max) of 2.2 ?g/mL achieved at 0.43 h (t(max)), and the absolute bioavailability (F) was 88.81%; and for the oral route the same parameters were 0.66 ± 0.15 ?g/mL, 1.54 ± 0.27 h and 74.42%. A multiple-peak phenomenon was present after oral administration. The plasma profile of valnemulin exhibited a secondary peak during 2-6 h and a tertiary peak at 32 h. The favorable PK behavior, such as the wide distribution, slow elimination and acceptable bioavailability indicated that it is likely to be effective in chickens.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1365-2885
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pubmed:author | |
pubmed:copyrightInfo |
© 2010 Blackwell Publishing Ltd.
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pubmed:issnType |
Electronic
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
247-51
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pubmed:meshHeading |
pubmed-meshheading:21492189-Administration, Oral,
pubmed-meshheading:21492189-Animals,
pubmed-meshheading:21492189-Anti-Bacterial Agents,
pubmed-meshheading:21492189-Biological Availability,
pubmed-meshheading:21492189-Chickens,
pubmed-meshheading:21492189-Chromatography, High Pressure Liquid,
pubmed-meshheading:21492189-Diterpenes,
pubmed-meshheading:21492189-Drug Administration Schedule,
pubmed-meshheading:21492189-Injections, Intramuscular,
pubmed-meshheading:21492189-Injections, Intravenous,
pubmed-meshheading:21492189-Random Allocation,
pubmed-meshheading:21492189-Tandem Mass Spectrometry
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pubmed:year |
2011
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pubmed:articleTitle |
Pharmacokinetics and bioavailability of valnemulin in broiler chickens.
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pubmed:affiliation |
Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Tianhe District, Guangzhou, Guangdong Province, People's Republic of China.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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