21491995

Source:http://linkedlifedata.com/resource/pubmed/id/21491995

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0025519, umls-concept:C0026447, umls-concept:C0040287, umls-concept:C0184959, umls-concept:C0220927, umls-concept:C1299003, umls-concept:C1451502
pubmed:issue	3
pubmed:dateCreated	2011-6-13
pubmed:abstractText	To investigate the metabolism of a new antiglaucoma difluoroprostaglandin, tafluprost, in ocular tissues and evaluate the distribution of the parent drug and its metabolites in ocular and systemic tissues after a single ocular administration to cynomolgus monkeys (Macaca fascicularis).
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9511091
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/(5Z)-7-((1R,2R..., http://linkedlifedata.com/resource/pubmed/chemical/Ophthalmic Solutions, http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandins F, http://linkedlifedata.com/resource/pubmed/chemical/Radioactive Tracers, http://linkedlifedata.com/resource/pubmed/chemical/tafluprost
pubmed:status	MEDLINE
pubmed:month	Jun
pubmed:issn	1557-7732
pubmed:author	pubmed-author:AkaishiTakahiroT, pubmed-author:BezwadaPadmaP, pubmed-author:FukanoYasufumiY, pubmed-author:KawazuKouichiK, pubmed-author:PellinenPerttiP
pubmed:issnType	Electronic
pubmed:volume	27
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	251-9
pubmed:dateRevised	2011-10-17
pubmed:meshHeading	pubmed-meshheading:21491995-Absorption, pubmed-meshheading:21491995-Acetylation, pubmed-meshheading:21491995-Animals, pubmed-meshheading:21491995-Biotransformation, pubmed-meshheading:21491995-Dose-Response Relationship, Drug, pubmed-meshheading:21491995-Eye, pubmed-meshheading:21491995-Feces, pubmed-meshheading:21491995-Female, pubmed-meshheading:21491995-Glaucoma, pubmed-meshheading:21491995-Half-Life, pubmed-meshheading:21491995-Hydrolysis, pubmed-meshheading:21491995-Injections, Intraocular, pubmed-meshheading:21491995-Intraocular Pressure, pubmed-meshheading:21491995-Macaca fascicularis, pubmed-meshheading:21491995-Male, pubmed-meshheading:21491995-Ophthalmic Solutions, pubmed-meshheading:21491995-Prostaglandins F, pubmed-meshheading:21491995-Radioactive Tracers, pubmed-meshheading:21491995-Tissue Distribution, pubmed-meshheading:21491995-Urine
pubmed:year	2011
pubmed:articleTitle	Metabolism and ocular tissue distribution of an antiglaucoma prostanoid, tafluprost, after ocular instillation to monkeys.
pubmed:affiliation	Research and Development Center, Santen Pharmaceutical Co., Ltd., Ikoma-shi, Nara, Japan. yasufumi.fukano@santen.co.jp
pubmed:publicationType	Journal Article