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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-4-14
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pubmed:abstractText |
The Asia-specific PLA2G7 994G-T transversion leads to V279F substitution within the lipoprotein-associated phospholipase-A2 (Lp-PLA?) and to absence of enzyme activity in plasma. This variant offers a unique natural experiment to assess the role of Lp-PLA? in the pathogenesis of coronary artery disease (CAD) in humans. Given conflicting results from mostly small studies, a large two-stage case-control study was warranted.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21490708-10051281,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
pubmed-author:CardonLonL,
pubmed-author:ChoEun-YoungEY,
pubmed-author:ChoHyun-JaiHJ,
pubmed-author:HanBok-GheeBG,
pubmed-author:JangHye-YoonHY,
pubmed-author:JangYangsooY,
pubmed-author:JeeSun HaSH,
pubmed-author:KimHyo-SooHS,
pubmed-author:KimSujinS,
pubmed-author:KuHyo JeongHJ,
pubmed-author:LeeBok-SooBS,
pubmed-author:LeeJong HoJH,
pubmed-author:LeeJong-EunJE,
pubmed-author:MooserVincentV,
pubmed-author:OhIl-YoungIY,
pubmed-author:ParkJeong EuyJE,
pubmed-author:ParkKyung WooKW,
pubmed-author:ShinDong-JikDJ,
pubmed-author:SongKijoungK,
pubmed-author:VallancePatrickP,
pubmed-author:WaterworthDawnD,
pubmed-author:WhittakerJohnJ
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e18208
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pubmed:meshHeading |
pubmed-meshheading:21490708-1-Alkyl-2-acetylglycerophosphocholine Esterase,
pubmed-meshheading:21490708-Alleles,
pubmed-meshheading:21490708-Asian Continental Ancestry Group,
pubmed-meshheading:21490708-Coronary Artery Disease,
pubmed-meshheading:21490708-Female,
pubmed-meshheading:21490708-Genetic Predisposition to Disease,
pubmed-meshheading:21490708-Genotype,
pubmed-meshheading:21490708-Humans,
pubmed-meshheading:21490708-Male,
pubmed-meshheading:21490708-Middle Aged,
pubmed-meshheading:21490708-Polymorphism, Single Nucleotide,
pubmed-meshheading:21490708-Republic of Korea
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pubmed:year |
2011
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pubmed:articleTitle |
Carriage of the V279F null allele within the gene encoding Lp-PLA? is protective from coronary artery disease in South Korean males.
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pubmed:affiliation |
Division of Cardiology, Cardiovascular Genome Center, Yonsei University College of Medicine, Yonsei, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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