21488899

Source:http://linkedlifedata.com/resource/pubmed/id/21488899

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0011306, umls-concept:C0871261, umls-concept:C1704632, umls-concept:C1706817, umls-concept:C2587213, umls-concept:C2911692
pubmed:issue	1
pubmed:dateCreated	2011-4-14
pubmed:abstractText	One of the most fundamental problems in immunology is the seemingly schizophrenic ability of the immune system to launch robust immunity against pathogens, while acquiring and maintaining a state of tolerance to the body's own tissues and the trillions of commensal microorganisms and food antigens that confront it every day. A fundamental role for the innate immune system, particularly dendritic cells (DCs), in orchestrating immunological tolerance has been appreciated, but emerging studies have highlighted the nature of the innate receptors and the signaling pathways that program DCs to a tolerogenic state. Furthermore, several studies have emphasized the major role played by cellular interactions and the microenvironment in programming tolerogenic DCs. Here, we review these studies and suggest that the innate control of tolerogenic responses can be viewed as different hierarchies of organization, in which DCs, their innate receptors and signaling networks, and their interactions with other cells and local microenvironments represent different levels of the hierarchy.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/R01 AI048638-06, http://linkedlifedata.com/resource/pubmed/grant/R01 AI048638-07, http://linkedlifedata.com/resource/pubmed/grant/R01 AI048638-08, http://linkedlifedata.com/resource/pubmed/grant/R01 DK057665-09, http://linkedlifedata.com/resource/pubmed/grant/R01 DK057665-10, http://linkedlifedata.com/resource/pubmed/grant/R01 DK057665-11, http://linkedlifedata.com/resource/pubmed/grant/R01 DK057665-12, http://linkedlifedata.com/resource/pubmed/grant/R01 DK057665-13, http://linkedlifedata.com/resource/pubmed/grant/R37 AI048638-09A1, http://linkedlifedata.com/resource/pubmed/grant/R37 AI048638-10, http://linkedlifedata.com/resource/pubmed/grant/R37 AI048638-11, http://linkedlifedata.com/resource/pubmed/grant/R37 AI048638-12, http://linkedlifedata.com/resource/pubmed/grant/U19 AI090023-01, http://linkedlifedata.com/resource/pubmed/grant/U19 AI090023-02
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7702118
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	May
pubmed:issn	1600-065X
pubmed:author	pubmed-author:ManicassamySanthakumarS, pubmed-author:PulendranBaliB
pubmed:copyrightInfo	© 2011 John Wiley & Sons A/S.
pubmed:issnType	Electronic
pubmed:volume	241
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	206-27
pubmed:dateRevised	2011-8-1
pubmed:meshHeading	pubmed-meshheading:21488899-Animals, pubmed-meshheading:21488899-Cell Communication, pubmed-meshheading:21488899-Dendritic Cells, pubmed-meshheading:21488899-Humans, pubmed-meshheading:21488899-Immune Tolerance, pubmed-meshheading:21488899-Immunity, Innate, pubmed-meshheading:21488899-Signal Transduction
pubmed:year	2011
pubmed:articleTitle	Dendritic cell control of tolerogenic responses.
pubmed:affiliation	Emory Vaccine Center, Yerkes National Primate Research Center, Department of Pathology, Emory University School of Medicine, Atlanta, GA 30329, USA.
pubmed:publicationType	Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural