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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-9-19
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pubmed:abstractText |
Oxysterols such as 24S-hydroxycholesterol (OHC) and 27-OHC are intermediates of cholesterol excretion pathways. In addition, they are putative endogenous agonists of the liver X receptor (LXR) class of nuclear hormone receptors and are thought to be important mediators of cholesterol-dependent gene regulation. 24S-OHC is one of the most efficient endogenous LXR agonists known and is present in the brain and in the circulation at relatively high levels.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1365-2796
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pubmed:author |
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pubmed:copyrightInfo |
© 2011 The Association for the Publication of the Journal of Internal Medicine.
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pubmed:issnType |
Electronic
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pubmed:volume |
270
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
377-87
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pubmed:meshHeading |
pubmed-meshheading:21486371-Animals,
pubmed-meshheading:21486371-Brain,
pubmed-meshheading:21486371-Female,
pubmed-meshheading:21486371-Gene Expression Profiling,
pubmed-meshheading:21486371-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:21486371-Humans,
pubmed-meshheading:21486371-Hydroxycholesterols,
pubmed-meshheading:21486371-Liver,
pubmed-meshheading:21486371-Male,
pubmed-meshheading:21486371-Mice,
pubmed-meshheading:21486371-Mice, Transgenic,
pubmed-meshheading:21486371-Orphan Nuclear Receptors,
pubmed-meshheading:21486371-Polymerase Chain Reaction,
pubmed-meshheading:21486371-Steroid Hydroxylases
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pubmed:year |
2011
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pubmed:articleTitle |
Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo.
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pubmed:affiliation |
Divisions of Clinical Chemistry and Clinical Research Center, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Huddinge, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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