Linked Life Data

21485836

Source:http://linkedlifedata.com/resource/pubmed/id/21485836

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2011-4-13
pubmed:abstractText
Approximately 50% active substances discovered by combinatorial chemistry and high-throughput screening show poor solubility in water. Out of various available approaches "Nanoedege technology" (Combination of Precipitation and Homogenization) was selected. Amphotericin B (Amp B) was used as a model drug. Three different preparations of Amp B were produced by using three different surfactants Tween80, Pluronic F68, Soya Lecithin and assessed for their efficacy and stability. In this study the Amp B nanosuspension formulation, with the smaller particle size, can be effectively produced with the Nanoedge Method. The pharmacokinetic profiles of Amp B when given in the nanosuspension formulation were different compared to the corresponding raw drug.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1550-7033
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
127-9
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Nanocrystallization of poorly water soluble drugs for parenteral administration.
pubmed:affiliation
Rayat Institute of Pharmacy, Ropar, Punjab 144533, India.
pubmed:publicationType
Journal Article