Linked Life Data

21485506

Source:http://linkedlifedata.com/resource/pubmed/id/21485506

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2011-4-12
pubmed:abstractText
Apoptosis (programmed cell death) is common to all multicellular organisms. Apoptosis can be triggered by the extrinsic (death receptor (DR)) or the intrinsic (mitochondrial) death pathways. Apoptosis plays the central role for the cell differentiation, removal of the damaged cells and the homeostasis of the immune system. CD95 (APO-1/Fas) is a member of the DR family, which was discovered more than 20 years ago. This review is focused on the mechanisms of DR-induced apoptosis focusing on CD95 (APO-1/Fas)-mediated apoptosis and the role of the anti-apoptotic protein c-FLIP in the extrinsic apoptosis. Regulation of apoptosis plays the central role in the immune system and apoptosis deregulation leads to a number of diseases. Gaining insights into these processes will improve our understanding of the pathogenesis of diseases such as cancer, autoimmunity and AIDS, and will open new approaches to rational treatment strategies.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0026-8984
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
173-9
pubmed:meshHeading
pubmed:articleTitle
[Regulation of death receptor-induced apoptosis induced via CD95/FAS and other death receptors].
pubmed:publicationType
Journal Article, English Abstract, Review, Research Support, Non-U.S. Gov't