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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-4-12
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pubmed:abstractText |
Traditional antibiotics are increasingly suffering from the emergence of multidrug resistance amongst pathogenic bacteria leading to a range of novel approaches to control microbial infections being investigated as potential alternative treatments. One plausible antimicrobial alternative could be the combination of conventional antimicrobial agents/antibiotics with small molecules which block multidrug efflux systems known as efflux pump inhibitors. Bioassay-driven purification and structural determination of compounds from plant sources have yielded a number of pump inhibitors which acted against gram positive bacteria.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21483731-10508015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21483731-10552750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21483731-10677479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21483731-10770791,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/21483731-18500841,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/21483731-18848780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21483731-19325113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21483731-19475447,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/21483731-9632250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21483731-9757107
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e18127
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pubmed:dateRevised |
2011-7-28
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pubmed:meshHeading |
pubmed-meshheading:21483731-Humans,
pubmed-meshheading:21483731-Animals,
pubmed-meshheading:21483731-Anti-Bacterial Agents,
pubmed-meshheading:21483731-Anti-Infective Agents,
pubmed-meshheading:21483731-Hemolysis,
pubmed-meshheading:21483731-Gram-Positive Bacteria,
pubmed-meshheading:21483731-Plant Extracts,
pubmed-meshheading:21483731-Berberine,
pubmed-meshheading:21483731-Quinic Acid,
pubmed-meshheading:21483731-Models, Molecular,
pubmed-meshheading:21483731-Protein Conformation,
pubmed-meshheading:21483731-Drug Synergism
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