Source:http://linkedlifedata.com/resource/pubmed/id/21482708
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2011-7-22
|
| pubmed:abstractText |
For establishing the true effect of different response categories in patients with multiple myeloma (MM) treated with autologous stem cell transplantation, we evaluated, after a median follow-up of 153 months, 344 patients with MM who received a transplant between 1989 and 1998. Overall survival (OS) at 12 years was 35% in complete response (CR) patients, 22% in near complete response (nCR), 16% in very good partial response (VGPR), and 16% in partial response (PR) groups. Significant differences in OS and progression-free survival were found between CR and nCR groups (P = .01 and P = .002, respectively), between CR and VGPR groups (P = .0001 and P = .003), or between CR and PR groups (P = .003 and P = < 10(-5)); no differences were observed between the nCR and VGPR groups (P = .2 and P = .9) or between these groups and the PR group (P = .1 and P = .8). A landmark study found a plateau phase in OS after 11 years; 35% patients in the CR group and 11% in the nCR+VGPR+PR group are alive at 17 years; 2 cases had relapsed in the nCR+VGPR+PR group. In conclusion, MM achieving CR after autologous stem cell transplantation is a central prognostic factor. The relapse rate is low in patients with > 11 years of follow-up, possibly signifying a cure for patients in CR.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
1528-0020
|
| pubmed:author |
pubmed-author:AlegreAdriánA,
pubmed-author:BesalduchJoanJ,
pubmed-author:BladeJoanJ,
pubmed-author:CabreraRafaelR,
pubmed-author:CondeEulogioE,
pubmed-author:García-LarañaJoséJ,
pubmed-author:García-RuizJuan CJC,
pubmed-author:Gomez del CastilloMaria CarmenMC,
pubmed-author:Gonzalez-San MiguelJosé DJD,
pubmed-author:GrandeCarlosC,
pubmed-author:Grupo Español de MM,
pubmed-author:Guzman-ZamudioJosé LuisJL,
pubmed-author:LahuertaJuan JoséJJ,
pubmed-author:Martinez-LopezJoaquinJ,
pubmed-author:MartinezRafaelR,
pubmed-author:MateosMaría-VictoriaMV,
pubmed-author:MoraledaJosé MariaJM,
pubmed-author:Programa para el Estudio de la Terapé utica en Hemopatía Maligna,
pubmed-author:San MiguelJesúsJ,
pubmed-author:SuredaAnnaA,
pubmed-author:ViguriaMaria CMC,
pubmed-author:de ArribaFelipeF,
pubmed-author:de la RubiaJavierJ
|
| pubmed:issnType |
Electronic
|
| pubmed:day |
21
|
| pubmed:volume |
118
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
529-34
|
| pubmed:meshHeading |
pubmed-meshheading:21482708-Female,
pubmed-meshheading:21482708-Follow-Up Studies,
pubmed-meshheading:21482708-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:21482708-Humans,
pubmed-meshheading:21482708-Male,
pubmed-meshheading:21482708-Middle Aged,
pubmed-meshheading:21482708-Multiple Myeloma,
pubmed-meshheading:21482708-Multivariate Analysis,
pubmed-meshheading:21482708-Prognosis,
pubmed-meshheading:21482708-Registries,
pubmed-meshheading:21482708-Remission Induction,
pubmed-meshheading:21482708-Retrospective Studies,
pubmed-meshheading:21482708-Survival Analysis
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Long-term prognostic significance of response in multiple myeloma after stem cell transplantation.
|
| pubmed:affiliation |
Hospital Universitario 12 de Octubre, Madrid, Spain.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|