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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0042769,
umls-concept:C0042776,
umls-concept:C0085358,
umls-concept:C0162638,
umls-concept:C0220847,
umls-concept:C0524910,
umls-concept:C0599894,
umls-concept:C1332717,
umls-concept:C1334123,
umls-concept:C1413244,
umls-concept:C1418401,
umls-concept:C1540292,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C1706438,
umls-concept:C2698600
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pubmed:issue |
2
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pubmed:dateCreated |
2011-6-1
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pubmed:abstractText |
PD-1 molecule promotes anergy and IL-7 receptor (CD127) induces an anti-apoptotic effect on T cells. Correlation between PD-1/CD127 phenotype and hepatitis C virus (HCV)-specific CD8(+) cell reactivity in resolved infection (RI) after treatment and persistent HCV-infection (PI) was analysed. Directly ex vivo, PD-1 and CD127 expression on HCV-specific CD8(+) cells displayed a positive and negative correlation, respectively with viraemia. Proliferation after stimulation on PD-1(-)/CD127(+) cells from RI cases was preserved, while it was impaired on PD-1(+)/CD127(-) cells from PI patients. PD1(+)/CD127(+) population was observed in PI, and these maintained expansion ability but they did not target the virus. Frequency of PI cases with HCV-specific CD8(+) cell proliferation increased after anti-PD-L1 and anti-apoptotic treatment. Bim expression on HCV-specific CD8(+) cells from PI patients was enhanced. In conclusion, during chronic HCV infection non-reactive HCV-specific CD8(+) cells targeting the virus are PD-1(+)/CD127(-)/Bim(+) and, blocking apoptosis and PD-1/PD-L1 pathway on them enhances in vitro reactivity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acid Chloromethyl Ketones,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD274,
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Bcl-2-like protein 11,
http://linkedlifedata.com/resource/pubmed/chemical/CD274 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-7 Receptor alpha Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NS3 protein, hepatitis C virus,
http://linkedlifedata.com/resource/pubmed/chemical/PDCD1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Programmed Cell Death 1 Receptor,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Nonstructural Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/benzyloxycarbonylvalyl-alanyl-aspart...
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pubmed:status |
MEDLINE
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pubmed:issn |
1090-2163
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
269
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
104-14
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:21481848-Adult,
pubmed-meshheading:21481848-Amino Acid Chloromethyl Ketones,
pubmed-meshheading:21481848-Antibodies, Monoclonal,
pubmed-meshheading:21481848-Antigens, CD,
pubmed-meshheading:21481848-Antigens, CD274,
pubmed-meshheading:21481848-Apoptosis,
pubmed-meshheading:21481848-Apoptosis Regulatory Proteins,
pubmed-meshheading:21481848-Cell Count,
pubmed-meshheading:21481848-Cell Proliferation,
pubmed-meshheading:21481848-Female,
pubmed-meshheading:21481848-Hepatitis C, Chronic,
pubmed-meshheading:21481848-Humans,
pubmed-meshheading:21481848-Immunophenotyping,
pubmed-meshheading:21481848-Interleukin-7 Receptor alpha Subunit,
pubmed-meshheading:21481848-Liver,
pubmed-meshheading:21481848-Lymphocyte Activation,
pubmed-meshheading:21481848-Lymphocyte Count,
pubmed-meshheading:21481848-Male,
pubmed-meshheading:21481848-Membrane Proteins,
pubmed-meshheading:21481848-Middle Aged,
pubmed-meshheading:21481848-Programmed Cell Death 1 Receptor,
pubmed-meshheading:21481848-Proto-Oncogene Proteins,
pubmed-meshheading:21481848-Signal Transduction,
pubmed-meshheading:21481848-T-Lymphocyte Subsets,
pubmed-meshheading:21481848-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:21481848-Viral Load,
pubmed-meshheading:21481848-Viral Nonstructural Proteins
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pubmed:year |
2011
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pubmed:articleTitle |
Bim-mediated apoptosis and PD-1/PD-L1 pathway impair reactivity of PD1(+)/CD127(-) HCV-specific CD8(+) cells targeting the virus in chronic hepatitis C virus infection.
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pubmed:affiliation |
Translational Hepatology Unit, Guadalajara University Hospital, University of Alcalá, Donante de Sangre st., 19002 Guadalajara, Spain. jlarrubiam@meditex.es
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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