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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-4-12
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pubmed:abstractText |
Glioblastomas display cellular hierarchies containing tumor-propagating glioblastoma stem cells (GSCs). STAT3 is a critical signaling node in GSC maintenance but molecular mechanisms underlying STAT3 activation in GSCs are poorly defined. Here we demonstrate that the bone marrow X-linked (BMX) nonreceptor tyrosine kinase activates STAT3 signaling to maintain self-renewal and tumorigenic potential of GSCs. BMX is differentially expressed in GSCs relative to nonstem cancer cells and neural progenitors. BMX knockdown potently inhibited STAT3 activation, expression of GSC transcription factors, and growth of GSC-derived intracranial tumors. Constitutively active STAT3 rescued the effects of BMX downregulation, supporting that BMX signals through STAT3 in GSCs. These data demonstrate that BMX represents a GSC therapeutic target and reinforces the importance of STAT3 signaling in stem-like cancer phenotypes.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BMX protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/OLIG2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1878-3686
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pubmed:author |
pubmed-author:BaoShidengS,
pubmed-author:BredelMarkusM,
pubmed-author:ChengLinL,
pubmed-author:EylerChristine ECE,
pubmed-author:GuryanovaOlga AOA,
pubmed-author:HambardzumyanDoloresD,
pubmed-author:HeddlestonJohn MJM,
pubmed-author:HjelmelandAnita BAB,
pubmed-author:HuangZhiZ,
pubmed-author:LathiaJustin DJD,
pubmed-author:LeeJeongwuJ,
pubmed-author:MacSwordsJenniferJ,
pubmed-author:McLendonRoger ERE,
pubmed-author:RichJeremy NJN,
pubmed-author:ShouWeinianW,
pubmed-author:SloanAndrew EAE,
pubmed-author:StarkGeorge RGR,
pubmed-author:WuQiulianQ,
pubmed-author:YangJinboJ
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
12
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
498-511
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pubmed:dateRevised |
2011-11-8
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pubmed:meshHeading |
pubmed-meshheading:21481791-Animals,
pubmed-meshheading:21481791-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:21481791-Brain Neoplasms,
pubmed-meshheading:21481791-Cell Line, Tumor,
pubmed-meshheading:21481791-Cell Proliferation,
pubmed-meshheading:21481791-Glioblastoma,
pubmed-meshheading:21481791-Humans,
pubmed-meshheading:21481791-Mice,
pubmed-meshheading:21481791-Mice, Inbred C57BL,
pubmed-meshheading:21481791-Neoplastic Stem Cells,
pubmed-meshheading:21481791-Nerve Tissue Proteins,
pubmed-meshheading:21481791-Protein-Tyrosine Kinases,
pubmed-meshheading:21481791-Receptors, Interleukin-6,
pubmed-meshheading:21481791-STAT3 Transcription Factor,
pubmed-meshheading:21481791-Vascular Endothelial Growth Factor A
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pubmed:year |
2011
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pubmed:articleTitle |
Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3.
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pubmed:affiliation |
Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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