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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-4-12
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pubmed:databankReference |
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pubmed:abstractText |
To identify oncogenic pathways in T cell acute lymphoblastic leukemia (T-ALL), we combined expression profiling of 117 pediatric patient samples and detailed molecular-cytogenetic analyses including the Chromosome Conformation Capture on Chip (4C) method. Two T-ALL subtypes were identified that lacked rearrangements of known oncogenes. One subtype associated with cortical arrest, expression of cell cycle genes, and ectopic NKX2-1 or NKX2-2 expression for which rearrangements were identified. The second subtype associated with immature T cell development and high expression of the MEF2C transcription factor as consequence of rearrangements of MEF2C, transcription factors that target MEF2C, or MEF2C-associated cofactors. We propose NKX2-1, NKX2-2, and MEF2C as T-ALL oncogenes that are activated by various rearrangements.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1878-3686
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pubmed:author |
pubmed-author:BeverlooH BernaHB,
pubmed-author:Buijs-GladdinesJessicaJ,
pubmed-author:CayuelaJean MichelJM,
pubmed-author:FerrandoAdolfo AAA,
pubmed-author:HommingaIreneI,
pubmed-author:HorstmannMartinM,
pubmed-author:KlousPetraP,
pubmed-author:KooiClarissaC,
pubmed-author:LangerakAnton WAW,
pubmed-author:MeijerinkJules P PJP,
pubmed-author:PietersRobR,
pubmed-author:Pike-OverzetKarinK,
pubmed-author:SigauxFrancoisF,
pubmed-author:SoulierJeanJ,
pubmed-author:StaalFrank J TFJ,
pubmed-author:StubbsAndrewA,
pubmed-author:VerhaafBrendaB,
pubmed-author:VerstegenMoniqueM,
pubmed-author:VuerhardMaartjeM,
pubmed-author:WiekmeijerAnna-SophiaAS,
pubmed-author:de HaasValerieV,
pubmed-author:de LaatWouterW,
pubmed-author:de RooiJohan JJJ,
pubmed-author:van VlierberghePieterP
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
12
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
484-97
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pubmed:dateRevised |
2011-7-13
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pubmed:meshHeading |
pubmed-meshheading:21481790-Adolescent,
pubmed-meshheading:21481790-Cell Proliferation,
pubmed-meshheading:21481790-Child,
pubmed-meshheading:21481790-Child, Preschool,
pubmed-meshheading:21481790-Cluster Analysis,
pubmed-meshheading:21481790-Female,
pubmed-meshheading:21481790-Gene Expression Regulation, Leukemic,
pubmed-meshheading:21481790-Gene Rearrangement,
pubmed-meshheading:21481790-Genome, Human,
pubmed-meshheading:21481790-Homeodomain Proteins,
pubmed-meshheading:21481790-Humans,
pubmed-meshheading:21481790-Infant,
pubmed-meshheading:21481790-MADS Domain Proteins,
pubmed-meshheading:21481790-Male,
pubmed-meshheading:21481790-Myogenic Regulatory Factors,
pubmed-meshheading:21481790-Nuclear Proteins,
pubmed-meshheading:21481790-Oncogenes,
pubmed-meshheading:21481790-Precursor T-Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:21481790-Transcription, Genetic,
pubmed-meshheading:21481790-Transcription Factors
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pubmed:year |
2011
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pubmed:articleTitle |
Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia.
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pubmed:affiliation |
Department of Pediatric Oncology/Hematology, Erasmus MC/Sophia Children's Hospital, Rotterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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