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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-4-12
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pubmed:databankReference |
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pubmed:abstractText |
p120-catenin (p120ctn) interacts with E-cadherin, but to our knowledge, no formal proof that p120ctn functions as a bona fide tumor suppressor gene has emerged to date. We report herein that p120ctn loss leads to tumor development in mice. We have generated a conditional knockout model of p120ctn whereby mice develop preneoplastic and neoplastic lesions in the oral cavity, esophagus, and squamous forestomach. Tumor-derived cells secrete granulocyte macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF), monocyte chemotactic protein-1 (MCP-1), and tumor necrosis factor-? (TNF?). The tumors contain significant desmoplasia and immune cell infiltration. Immature myeloid cells comprise a significant percentage of the immune cells present and likely participate in fostering a favorable tumor microenvironment, including the activation of fibroblasts.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/50CA95103,
http://linkedlifedata.com/resource/pubmed/grant/CA055724,
http://linkedlifedata.com/resource/pubmed/grant/CA111947,
http://linkedlifedata.com/resource/pubmed/grant/F32-CA1308513,
http://linkedlifedata.com/resource/pubmed/grant/K99/R00-CA138498,
http://linkedlifedata.com/resource/pubmed/grant/P01 CA098101-08,
http://linkedlifedata.com/resource/pubmed/grant/P01-CA098101,
http://linkedlifedata.com/resource/pubmed/grant/P30-CA016520,
http://linkedlifedata.com/resource/pubmed/grant/P30-DK050306,
http://linkedlifedata.com/resource/pubmed/grant/R01-DK069984,
http://linkedlifedata.com/resource/pubmed/grant/T32-CA115299,
http://linkedlifedata.com/resource/pubmed/grant/U01 CA143056-03,
http://linkedlifedata.com/resource/pubmed/grant/U01-CA143056
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1878-3686
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pubmed:author |
pubmed-author:BayneLauren JLJ,
pubmed-author:DiehlJ AlanJA,
pubmed-author:KalabisJiriJ,
pubmed-author:KatzJonathan PJP,
pubmed-author:Klein-SzantoAndresA,
pubmed-author:LeeJu-SeogJS,
pubmed-author:ReynoldsAlbert BAB,
pubmed-author:RhoadesBenB,
pubmed-author:RustgiAnil KAK,
pubmed-author:StairsDouglas BDB,
pubmed-author:VegaMaria EME,
pubmed-author:VonderheideRobert HRH,
pubmed-author:WaldronTodd JTJ
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
12
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
470-83
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:21481789-Animals,
pubmed-meshheading:21481789-Cadherins,
pubmed-meshheading:21481789-Carcinoma, Squamous Cell,
pubmed-meshheading:21481789-Catenins,
pubmed-meshheading:21481789-Cell Differentiation,
pubmed-meshheading:21481789-Cell Line, Tumor,
pubmed-meshheading:21481789-Cell Proliferation,
pubmed-meshheading:21481789-Esophageal Neoplasms,
pubmed-meshheading:21481789-Fibroblasts,
pubmed-meshheading:21481789-Genes, Tumor Suppressor,
pubmed-meshheading:21481789-Humans,
pubmed-meshheading:21481789-Inflammation,
pubmed-meshheading:21481789-Mice,
pubmed-meshheading:21481789-Mouth Neoplasms,
pubmed-meshheading:21481789-Myeloid Cells,
pubmed-meshheading:21481789-NF-kappa B
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pubmed:year |
2011
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pubmed:articleTitle |
Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene.
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pubmed:affiliation |
Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA 19104, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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