Linked Life Data

2148061

Source:http://linkedlifedata.com/resource/pubmed/id/2148061

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6 Pt 2
pubmed:dateCreated
1991-1-31
pubmed:abstractText
Treatments that increase central extracellular serotonin (5-HT) also increase Na excretion. Efferent renal sympathetic nerve activity (ERSNA) contributes to the control of Na and water reabsorption. To determine whether renal nerves play a role in the 5-HT-induced natriuresis, we examined the effect of intracerebroventricular (icv) injection of vehicle or 5-HT (20 micrograms) on Na, K, and urine excretion rates, as well as mean arterial pressure and heart rate in unanesthetized, hydrated rats with renal nerves intact or sectioned. Renal denervation attenuated the natriuresis produced by 5-HT but not the antidiuresis observed 15-30 min after injection. Central 5-HT produced brief pressor and bradycardic responses, followed by continued bradycardia and hypotension, which were more pronounced in intact rats. In other experiments, circulating levels of arginine vasopressin (AVP) and plasma atrial natriuretic polypeptide (ANP) were measured 15 min after icv injection of 5-HT. 5-HT significantly increased circulating AVP, but plasma ANP remained unchanged. These results suggest that renal nerves participate in the natriuresis elicited by centrally administered 5-HT through a decrease in ERSNA. The antidiuresis observed after central 5-HT may be due to an increase in AVP release.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
259
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R1267-73
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Efferent mechanisms mediating renal sodium and water excretion induced by centrally administered serotonin.
pubmed:affiliation
Department of Psychology, University of Iowa, Iowa City 52242.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't