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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2011-4-7
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pubmed:abstractText |
Although meta-analyses are typically viewed as retrospective activities, they are increasingly being applied prospectively to provide up-to-date evidence on specific research questions. When meta-analyses are updated account should be taken of the possibility of false-positive findings due to repeated significance tests. We discuss the use of sequential methods for meta-analyses that incorporate random effects to allow for heterogeneity across studies. We propose a method that uses an approximate semi-Bayes procedure to update evidence on the among-study variance, starting with an informative prior distribution that might be based on findings from previous meta-analyses. We compare our methods with other approaches, including the traditional method of cumulative meta-analysis, in a simulation study and observe that it has Type I and Type II error rates close to the nominal level. We illustrate the method using an example in the treatment of bleeding peptic ulcers.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-10193281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-15996966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-16345038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-16596572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-16981184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-17028503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-17848494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-1792461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-18063673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-18083463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-18362232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-18411040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-19475538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-20499329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-20499330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-20499331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-2142225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-21969254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-2691203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-3802833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-4089353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-497341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-8261256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-8731004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-8854238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-8932970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-8981683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-9131763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-9310563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-9408720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21472757-9483722
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1097-0258
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 John Wiley & Sons, Ltd.
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pubmed:issnType |
Electronic
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pubmed:day |
30
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
903-21
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pubmed:dateRevised |
2011-11-7
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pubmed:meshHeading |
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pubmed:year |
2011
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pubmed:articleTitle |
Sequential methods for random-effects meta-analysis.
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pubmed:affiliation |
MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 0SR, U.K. julian.higgins@mrc-bsu.cam.ac.uk
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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