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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2011-4-28
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pubmed:abstractText |
Increased plasma concentrations of apolipoprotein B100 often present in patients with insulin resistance and confer increased risk for the development of atherosclerosis. Naturally occurring polyphenolic compounds including flavonoids have antiatherogenic properties. The aim of the current study was to evaluate the effect of the polymethoxylated flavonoid nobiletin on lipoprotein secretion in cultured human hepatoma cells (HepG2) and in a mouse model of insulin resistance and atherosclerosis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Butadienes,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Flavones,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin Receptor Substrate Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, VLDL,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/MAP2K1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MAP2K2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nitriles,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides,
http://linkedlifedata.com/resource/pubmed/chemical/U 0126,
http://linkedlifedata.com/resource/pubmed/chemical/nobiletin,
http://linkedlifedata.com/resource/pubmed/chemical/very low density lipoprotein...
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1939-327X
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pubmed:author |
pubmed-author:AllisterEmma MEM,
pubmed-author:AssiniJulia MJM,
pubmed-author:CharbonneauAlexandreA,
pubmed-author:EdwardsJane YJY,
pubmed-author:HuffMurray WMW,
pubmed-author:KoppesJulie BJB,
pubmed-author:LeeJustin KJK,
pubmed-author:MaretteAndréA,
pubmed-author:MulvihillErin EEE,
pubmed-author:SawyezCynthia GCG,
pubmed-author:St-PierrePhilippeP,
pubmed-author:SutherlandBrian GBG,
pubmed-author:TelfordDawn EDE
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pubmed:issnType |
Electronic
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1446-57
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:21471511-Animals,
pubmed-meshheading:21471511-Atherosclerosis,
pubmed-meshheading:21471511-Butadienes,
pubmed-meshheading:21471511-Diet,
pubmed-meshheading:21471511-Dyslipidemias,
pubmed-meshheading:21471511-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:21471511-Energy Metabolism,
pubmed-meshheading:21471511-Enzyme Inhibitors,
pubmed-meshheading:21471511-Flavones,
pubmed-meshheading:21471511-Hep G2 Cells,
pubmed-meshheading:21471511-Humans,
pubmed-meshheading:21471511-Insulin,
pubmed-meshheading:21471511-Insulin Receptor Substrate Proteins,
pubmed-meshheading:21471511-Insulin Resistance,
pubmed-meshheading:21471511-Lipoproteins, VLDL,
pubmed-meshheading:21471511-MAP Kinase Kinase 1,
pubmed-meshheading:21471511-MAP Kinase Kinase 2,
pubmed-meshheading:21471511-Male,
pubmed-meshheading:21471511-Mice,
pubmed-meshheading:21471511-Mice, Mutant Strains,
pubmed-meshheading:21471511-Nitriles,
pubmed-meshheading:21471511-Phosphorylation,
pubmed-meshheading:21471511-Receptor, Insulin,
pubmed-meshheading:21471511-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21471511-Signal Transduction,
pubmed-meshheading:21471511-Triglycerides
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pubmed:year |
2011
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pubmed:articleTitle |
Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance.
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pubmed:affiliation |
Vascular Biology, Robarts Research Institute, London, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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