| pubmed-article:21471449 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21471449 | lifeskim:mentions | umls-concept:C0040113 | lld:lifeskim |
| pubmed-article:21471449 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:21471449 | lifeskim:mentions | umls-concept:C1817960 | lld:lifeskim |
| pubmed-article:21471449 | lifeskim:mentions | umls-concept:C0205100 | lld:lifeskim |
| pubmed-article:21471449 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:21471449 | pubmed:dateCreated | 2011-5-4 | lld:pubmed |
| pubmed-article:21471449 | pubmed:abstractText | The thymus mainly contains developing thymocytes that undergo thymic selection. In addition, some mature activated peripheral T cells can re-enter the thymus. We demonstrated in this study that adoptively transferred syngeneic Ag-specific T cells can enter the thymus of lymphopenic mice, where they delete thymic dendritic cells and medullary thymic epithelial cells in an Ag-specific fashion, without altering general thymic functions. This induced sustained thymic release of autoreactive self-Ag-specific T cells suggested that adoptively transferred activated T cells can specifically alter the endogenous T cell repertoire by erasing negative selection of their own specificities. Especially in clinical settings in which adoptively transferred T cells cause graft-versus-host disease or graft-versus-leukemia, as well as in adoptive tumor therapies, these findings might be of importance, because the endogenous T cell repertoire might be skewed to contribute to both manifestations. | lld:pubmed |
| pubmed-article:21471449 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21471449 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21471449 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:21471449 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21471449 | pubmed:month | May | lld:pubmed |
| pubmed-article:21471449 | pubmed:issn | 1550-6606 | lld:pubmed |
| pubmed-article:21471449 | pubmed:author | pubmed-author:BrockerThomas... | lld:pubmed |
| pubmed-article:21471449 | pubmed:author | pubmed-author:MarconiPeggyP | lld:pubmed |
| pubmed-article:21471449 | pubmed:author | pubmed-author:EdelmannSteph... | lld:pubmed |
| pubmed-article:21471449 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21471449 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:21471449 | pubmed:volume | 186 | lld:pubmed |
| pubmed-article:21471449 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21471449 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21471449 | pubmed:pagination | 5612-9 | lld:pubmed |
| pubmed-article:21471449 | pubmed:meshHeading | pubmed-meshheading:21471449... | lld:pubmed |
| pubmed-article:21471449 | pubmed:meshHeading | pubmed-meshheading:21471449... | lld:pubmed |
| pubmed-article:21471449 | pubmed:meshHeading | pubmed-meshheading:21471449... | lld:pubmed |
| pubmed-article:21471449 | pubmed:meshHeading | pubmed-meshheading:21471449... | lld:pubmed |
| pubmed-article:21471449 | pubmed:meshHeading | pubmed-meshheading:21471449... | lld:pubmed |
| pubmed-article:21471449 | pubmed:meshHeading | pubmed-meshheading:21471449... | lld:pubmed |
| pubmed-article:21471449 | pubmed:meshHeading | pubmed-meshheading:21471449... | lld:pubmed |
| pubmed-article:21471449 | pubmed:meshHeading | pubmed-meshheading:21471449... | lld:pubmed |
| pubmed-article:21471449 | pubmed:meshHeading | pubmed-meshheading:21471449... | lld:pubmed |
| pubmed-article:21471449 | pubmed:meshHeading | pubmed-meshheading:21471449... | lld:pubmed |
| pubmed-article:21471449 | pubmed:meshHeading | pubmed-meshheading:21471449... | lld:pubmed |
| pubmed-article:21471449 | pubmed:meshHeading | pubmed-meshheading:21471449... | lld:pubmed |
| pubmed-article:21471449 | pubmed:meshHeading | pubmed-meshheading:21471449... | lld:pubmed |
| pubmed-article:21471449 | pubmed:meshHeading | pubmed-meshheading:21471449... | lld:pubmed |
| pubmed-article:21471449 | pubmed:meshHeading | pubmed-meshheading:21471449... | lld:pubmed |
| pubmed-article:21471449 | pubmed:meshHeading | pubmed-meshheading:21471449... | lld:pubmed |
| pubmed-article:21471449 | pubmed:meshHeading | pubmed-meshheading:21471449... | lld:pubmed |
| pubmed-article:21471449 | pubmed:meshHeading | pubmed-meshheading:21471449... | lld:pubmed |
| pubmed-article:21471449 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21471449 | pubmed:articleTitle | Peripheral T cells re-enter the thymus and interfere with central tolerance induction. | lld:pubmed |
| pubmed-article:21471449 | pubmed:affiliation | Institute for Immunology, Ludwig-Maximilians-University, D-80336 Munich, Germany. | lld:pubmed |
| pubmed-article:21471449 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21471449 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
