Source:http://linkedlifedata.com/resource/pubmed/id/21471449
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2011-5-4
|
| pubmed:abstractText |
The thymus mainly contains developing thymocytes that undergo thymic selection. In addition, some mature activated peripheral T cells can re-enter the thymus. We demonstrated in this study that adoptively transferred syngeneic Ag-specific T cells can enter the thymus of lymphopenic mice, where they delete thymic dendritic cells and medullary thymic epithelial cells in an Ag-specific fashion, without altering general thymic functions. This induced sustained thymic release of autoreactive self-Ag-specific T cells suggested that adoptively transferred activated T cells can specifically alter the endogenous T cell repertoire by erasing negative selection of their own specificities. Especially in clinical settings in which adoptively transferred T cells cause graft-versus-host disease or graft-versus-leukemia, as well as in adoptive tumor therapies, these findings might be of importance, because the endogenous T cell repertoire might be skewed to contribute to both manifestations.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
1550-6606
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
15
|
| pubmed:volume |
186
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
5612-9
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| pubmed:meshHeading |
pubmed-meshheading:21471449-Adoptive Transfer,
pubmed-meshheading:21471449-Animals,
pubmed-meshheading:21471449-Autoimmunity,
pubmed-meshheading:21471449-CD8-Positive T-Lymphocytes,
pubmed-meshheading:21471449-Cell Movement,
pubmed-meshheading:21471449-Chimera,
pubmed-meshheading:21471449-Dendritic Cells,
pubmed-meshheading:21471449-Epithelial Cells,
pubmed-meshheading:21471449-Flow Cytometry,
pubmed-meshheading:21471449-Graft vs Host Disease,
pubmed-meshheading:21471449-Graft vs Leukemia Effect,
pubmed-meshheading:21471449-Lymphocyte Activation,
pubmed-meshheading:21471449-Lymphopenia,
pubmed-meshheading:21471449-Mice,
pubmed-meshheading:21471449-Mice, Inbred C57BL,
pubmed-meshheading:21471449-Polymerase Chain Reaction,
pubmed-meshheading:21471449-Self Tolerance,
pubmed-meshheading:21471449-Thymus Gland
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Peripheral T cells re-enter the thymus and interfere with central tolerance induction.
|
| pubmed:affiliation |
Institute for Immunology, Ludwig-Maximilians-University, D-80336 Munich, Germany.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|