Linked Life Data

21471442

Source:http://linkedlifedata.com/resource/pubmed/id/21471442

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2011-5-4
pubmed:abstractText
Earlier, we demonstrated the essential role of Kruppel-like transcription factor, TIEG1, in TGF-?-induced regulatory T cell (Treg) development. In this article, we demonstrate that IL-6, which promotes Th17 development, abrogated TIEG1 nuclear translocation and inhibited TGF-?-induced Treg development. Tyrosine kinase Tyk2-mediated phosphorylation of TIEG1 at Tyr179 promoted noncanonical K-27-linked polyubiquitination, which inhibited TIEG1 nuclear translocation. To test the role of TIEG1-regulated Treg/Th17 development in antitumor immunity, we analyzed TRAMP-C2 tumor growth in TIEG1(-/-) mice. The defective Treg development and elevated Th17 response resulted in enhanced immune reactivity in the tumor and inhibition of TRAMP-C2 tumor growth in TIEG1(-/-) mice. Thus, our results uncovered a novel regulatory mechanism that modulates Tregs and may regulate tumor progression.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1550-6606
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
186
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5638-47
pubmed:meshHeading
pubmed-meshheading:21471442-Active Transport, Cell Nucleus, pubmed-meshheading:21471442-Adoptive Transfer, pubmed-meshheading:21471442-Animals, pubmed-meshheading:21471442-Blotting, Western, pubmed-meshheading:21471442-Cell Nucleus, pubmed-meshheading:21471442-Cell Proliferation, pubmed-meshheading:21471442-DNA-Binding Proteins, pubmed-meshheading:21471442-Flow Cytometry, pubmed-meshheading:21471442-Forkhead Transcription Factors, pubmed-meshheading:21471442-Immunoprecipitation, pubmed-meshheading:21471442-Interleukin-6, pubmed-meshheading:21471442-Mice, pubmed-meshheading:21471442-Mice, Inbred C57BL, pubmed-meshheading:21471442-Mice, Transgenic, pubmed-meshheading:21471442-Neoplasms, Experimental, pubmed-meshheading:21471442-Phosphorylation, pubmed-meshheading:21471442-Polymerase Chain Reaction, pubmed-meshheading:21471442-Receptors, Antigen, T-Cell, pubmed-meshheading:21471442-Signal Transduction, pubmed-meshheading:21471442-T-Lymphocytes, Regulatory, pubmed-meshheading:21471442-TYK2 Kinase, pubmed-meshheading:21471442-Th17 Cells, pubmed-meshheading:21471442-Transcription Factors, pubmed-meshheading:21471442-Transforming Growth Factor beta, pubmed-meshheading:21471442-Ubiquitination
pubmed:year
2011
pubmed:articleTitle
Noncanonical K27-linked polyubiquitination of TIEG1 regulates Foxp3 expression and tumor growth.
pubmed:affiliation
Karmanos Cancer Institute, Detroit, MI 48201, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural