Source:http://linkedlifedata.com/resource/pubmed/id/21471252
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
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| pubmed:dateCreated |
2011-7-1
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| pubmed:abstractText |
Emerging evidence suggests that the tumor suppressor p53 is also a crucial regulator for many physiological processes. Previous observations indicate that p53 suppresses inflammation by inhibiting inflammatory antigen-presenting cells. To investigate the potential role of p53 in autoimmune effector T cells, we generated p53(null)CD45.1 mice by crossing p53(null)CD45.2 and CD45.1 mice. We demonstrate that p53(null)CD45.1 mice spontaneously developed autoimmunity, with a significant increase in IL-17-producing Th17 effectors in their lymph nodes (4.7 ± 1.0%) compared to the age-matched counterparts (1.9 ± 0.8% for p53(null)CD45.2, 1.1 ± 0.2% for CD45.1, and 0.5 ± 0.1% for CD45.2 mice). Likewise, p53(null)CD45.1 mice possess highly elevated serum levels of inflammatory cytokines IL-17 and IL-6. This enhanced Th17 response results largely from an increased sensitivity of p53(null)CD45.1 T cells to IL-6-induced STAT3 phosphorylation. Administration of STAT3 inhibitor S31-201 (IC50 of 38.0 ± 7.2 ?M for IL-6-induced STAT3 phosphorylation), but not PBS control, to p53(null)CD45.1 mice suppressed Th17 effectors and alleviated autoimmune pathology. This is the first report revealing that p53 activity in T cells suppresses autoimmunity by controlling Th17 effectors. This study suggests that p53 serves as a guardian of immunological functions and that the p53-STAT3-Th17 axis might be a therapeutic target for autoimmunity.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD45,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-17,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Ptprc protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
1530-6860
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
25
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2387-98
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| pubmed:meshHeading |
pubmed-meshheading:21471252-Animals,
pubmed-meshheading:21471252-Antigens, CD45,
pubmed-meshheading:21471252-Autoimmunity,
pubmed-meshheading:21471252-Blotting, Western,
pubmed-meshheading:21471252-CD4-Positive T-Lymphocytes,
pubmed-meshheading:21471252-Cytokines,
pubmed-meshheading:21471252-Female,
pubmed-meshheading:21471252-Flow Cytometry,
pubmed-meshheading:21471252-Interleukin-17,
pubmed-meshheading:21471252-Interleukin-6,
pubmed-meshheading:21471252-Lymphoid Tissue,
pubmed-meshheading:21471252-Male,
pubmed-meshheading:21471252-Mice,
pubmed-meshheading:21471252-Mice, Congenic,
pubmed-meshheading:21471252-Mice, Knockout,
pubmed-meshheading:21471252-NF-kappa B,
pubmed-meshheading:21471252-Phosphorylation,
pubmed-meshheading:21471252-STAT3 Transcription Factor,
pubmed-meshheading:21471252-Signal Transduction,
pubmed-meshheading:21471252-Th1 Cells,
pubmed-meshheading:21471252-Th17 Cells,
pubmed-meshheading:21471252-Tumor Suppressor Protein p53
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| pubmed:year |
2011
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| pubmed:articleTitle |
Trp53 negatively regulates autoimmunity via the STAT3-Th17 axis.
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| pubmed:affiliation |
Gene Therapy Program, Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, 533 Bolivar St., New Orleans, LA 70112, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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