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| pubmed-article:21470888 | lifeskim:mentions | umls-concept:C0242692 | lld:lifeskim |
| pubmed-article:21470888 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:21470888 | lifeskim:mentions | umls-concept:C0027100 | lld:lifeskim |
| pubmed-article:21470888 | lifeskim:mentions | umls-concept:C0311400 | lld:lifeskim |
| pubmed-article:21470888 | lifeskim:mentions | umls-concept:C1521970 | lld:lifeskim |
| pubmed-article:21470888 | lifeskim:mentions | umls-concept:C0699748 | lld:lifeskim |
| pubmed-article:21470888 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:21470888 | lifeskim:mentions | umls-concept:C0445223 | lld:lifeskim |
| pubmed-article:21470888 | lifeskim:mentions | umls-concept:C1552599 | lld:lifeskim |
| pubmed-article:21470888 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:21470888 | lifeskim:mentions | umls-concept:C1704787 | lld:lifeskim |
| pubmed-article:21470888 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:21470888 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:21470888 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:21470888 | pubmed:dateCreated | 2011-6-7 | lld:pubmed |
| pubmed-article:21470888 | pubmed:abstractText | Type 2 diabetes patients exhibit a reduction in oxidative muscle fibres and an increase in glycolytic muscle fibres. In this study, we investigated whether both genetic and non-genetic factors influence the mRNA expression levels of three myosin heavy chain (MHC) genes represented in different fibre types. Specifically, we examined the MHC7 (slow-twitch oxidative fibre), MHCIIa (fast-twitch oxidative fibre) and MHCIIx/d (fast-twitch glycolytic fibre) genes in human skeletal muscle. We further investigated the use of MHC mRNA expression as a proxy to determine fibre-type composition, as measured by traditional ATP staining. Two cohorts of age-matched Swedish men were studied to determine the relationship of muscle mRNA expression of MHC7, MHCIIa, and MHCIIx/d with muscle fibre composition. A classical twin approach, including young and elderly Danish twin pairs, was utilised to examine if differences in expression levels were due to genetic or environmental factors. Although MHCIIx/d mRNA expression correlated positively with the level of type IIx/d muscle fibres in the two cohorts (P<0.05), a relatively low magnitude of correlation suggests that mRNA does not fully correlate with fibre-type composition. Heritability estimates and genetic analysis suggest that the levels of MHC7, MHCIIa and MHCIIx/d expression are primarily under non-genetic influence, and MHCIIa indicated an age-related decline. PGC-1? exhibited a positive relationship with the expression of all three MHC genes (P<0.05); meanwhile, PGC-1? related positively with MHCIIa expression and negatively with MHCIIx/d expression (P<0.05). While MHCIIa expression related positively with insulin-stimulated glucose uptake (P<0.01), MHCIIx/d expression related negatively with insulin-stimulated glucose uptake (P<0.05). Our findings suggest that the expression levels of the MHC genes are associated with age and both PGC-1? and PGC-1? and indicate that the MHC genes may to some extent be used to determine fibre-type composition in human skeletal muscle. | lld:pubmed |
| pubmed-article:21470888 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21470888 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21470888 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:21470888 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21470888 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:21470888 | pubmed:issn | 1096-7206 | lld:pubmed |
| pubmed-article:21470888 | pubmed:author | pubmed-author:VaagAllanA | lld:pubmed |
| pubmed-article:21470888 | pubmed:author | pubmed-author:GroopLeifL | lld:pubmed |
| pubmed-article:21470888 | pubmed:author | pubmed-author:PoulsenPernil... | lld:pubmed |
| pubmed-article:21470888 | pubmed:author | pubmed-author:ErikssonKarl-... | lld:pubmed |
| pubmed-article:21470888 | pubmed:author | pubmed-author:HanssonOlaO | lld:pubmed |
| pubmed-article:21470888 | pubmed:author | pubmed-author:LingCharlotte... | lld:pubmed |
| pubmed-article:21470888 | pubmed:author | pubmed-author:RönnTinaT | lld:pubmed |
| pubmed-article:21470888 | pubmed:author | pubmed-author:OlssonAnders... | lld:pubmed |
| pubmed-article:21470888 | pubmed:author | pubmed-author:ElgzyriTarqT | lld:pubmed |
| pubmed-article:21470888 | pubmed:copyrightInfo | Copyright © 2011 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:21470888 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21470888 | pubmed:volume | 103 | lld:pubmed |
| pubmed-article:21470888 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21470888 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21470888 | pubmed:pagination | 275-81 | lld:pubmed |
| pubmed-article:21470888 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:21470888 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21470888 | pubmed:articleTitle | The expression of myosin heavy chain (MHC) genes in human skeletal muscle is related to metabolic characteristics involved in the pathogenesis of type 2 diabetes. | lld:pubmed |
| pubmed-article:21470888 | pubmed:affiliation | Lund University, Department of Clinical Sciences Malmö, Lund University Diabetes Centre, Scania University Hospital, Malmö, Sweden. anders_h.olsson@med.lu.se | lld:pubmed |
| pubmed-article:21470888 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21470888 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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