Linked Life Data

21470497

Source:http://linkedlifedata.com/resource/pubmed/id/21470497

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2011-4-7
pubmed:abstractText
Concerning the key role of interferon-? (IFN-?) in the protective immunity against Mycobacterium tuberculosis, we aimed to find the possible association between single nucleotide polymorphism of IFN-? +874T/A (rs61923114) and pulmonary tuberculosis (PTB). This case-control study was performed on 142 PTB patients and 166 healthy subjects. Genotype analysis was done using amplification refractory mutation system-PCR (ARMS-PCR). We found that the AA genotype of +874A/T IFN-? is a risk factor for PTB (OR = 3.333, 95% CI = 1.537-7.236, p=0.002). The results showed that the +874A allele frequency was higher in PTB than in normal subjects (OR = 1.561, 95% CI = 1.134-2.480, p=0.007). In conclusion, significant association was found between the IFN-? +874T/A polymorphism (rs61923114) and susceptibility to PTB in a sample of Iranian population.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1214-6994
pubmed:author
pubmed:issnType
Print
pubmed:volume
112
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
38-43
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Functional polymorphism of interferon-? (IFN-?) gene +874T/A polymorphism is associated with pulmonary tuberculosis in Zahedan, Southeast Iran.
pubmed:affiliation
Department of Clinical Biochemistry, Zahedan University of Medical Sciences, Zahedan, Iran. mhd.hashemi@gmail.com
pubmed:publicationType
Journal Article