Linked Life Data

2147043

Source:http://linkedlifedata.com/resource/pubmed/id/2147043

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1991-1-3
pubmed:abstractText
The potential for bovine collagen-impregnated vascular prostheses to stimulate an immune response was tested in 128 patients randomized prospectively to receive either a Dacron graft or a Dacron graft with collagen coating. Clinical variables and laboratory tests for antibovine collagen antibody were used to identify patients who developed humoral immunity up to 6 months after graft implantation. In a subgroup of 20 subjects, a lymphocyte proliferation assay by freshly isolated leukocytes was used to test for cell-mediated immune response. Of the patients randomized to receive a collagen-coated graft, five showed seroconversion to bovine, type I collagen. Seroconversion also occurred in one of the patients randomized to the noncollagen coated graft. No patient had a positive lymphocyte proliferation response, indicating an absence of cell-mediated immune response. No evidence for the development of cross-reactivity with human collagen was seen. The potential for bovine collagen to stimulate an immune response after implantation of a collagen-coated graft is low. The response is weak, and when it does occur it appears to be without clinical consequences.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0741-5214
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:pagination
741-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Immunologic response to collagen-impregnated vascular grafts: a randomized prospective study. The Canadian Multicenter Hemashield Study Group.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial, Multicenter Study