Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2011-6-21
pubmed:abstractText
Incidence rates of Parkinson's disease are higher in men than in women at all ages, and these differences may be a result of the neuroprotective effects of estrogen on the nigrostriatal pathway. We investigated the association of common variants in 4 estrogen-related genes with Parkinson's disease. Tagging single-nucleotide polymorphisms in the CYP19A1, ESR1, ESR2, and PRDM2 genes were selected from the International Haplotype Map and genotyped in 1103 Parkinson's disease cases from the upper Midwest of the United States and in 1103 individually matched controls (654 unaffected siblings, and 449 unrelated controls from the same region). Of 137 informative single-nucleotide polymorphisms, 2 PRDM2 single-nucleotide polymorphisms were significantly associated with an increased risk of Parkinson's disease at the Bonferroni-corrected significance level of 0.0004 (rs2744690: OR, 1.54; SE(logOR), .109; 99.96% CI, 1.05-2.26; uncorrected P = .0001; rs2744687: OR, 1.53; SE(logOR), .113; 99.96% CI, 1.03-2.29, uncorrected P = .0002); the association was significant in the women-only stratum but not in the men-only stratum. An additional 6 single-nucleotide polymorphisms in PRDM2, 2 in ESR1, 1 in ESR2, and 1 in CYP19A1 had significant P values in the overall sample before Bonferroni correction. None of the single-nucleotide polymorphisms were significantly associated with age at onset of Parkinson's disease after Bonferroni correction. Our results confirm the association of PRDM2 variants with Parkinson's disease susceptibility, especially in women.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1531-8257
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Movement Disorder Society.
pubmed:issnType
Electronic
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1234-42
pubmed:meshHeading
pubmed-meshheading:21469201-Adult, pubmed-meshheading:21469201-Age of Onset, pubmed-meshheading:21469201-Aged, pubmed-meshheading:21469201-Aged, 80 and over, pubmed-meshheading:21469201-Aromatase, pubmed-meshheading:21469201-Case-Control Studies, pubmed-meshheading:21469201-DNA-Binding Proteins, pubmed-meshheading:21469201-Estrogen Receptor alpha, pubmed-meshheading:21469201-Estrogen Receptor beta, pubmed-meshheading:21469201-Female, pubmed-meshheading:21469201-Genetic Predisposition to Disease, pubmed-meshheading:21469201-Genetic Variation, pubmed-meshheading:21469201-Histone-Lysine N-Methyltransferase, pubmed-meshheading:21469201-Humans, pubmed-meshheading:21469201-Linkage Disequilibrium, pubmed-meshheading:21469201-Male, pubmed-meshheading:21469201-Middle Aged, pubmed-meshheading:21469201-Nuclear Proteins, pubmed-meshheading:21469201-Parkinson Disease, pubmed-meshheading:21469201-Polymorphism, Single Nucleotide, pubmed-meshheading:21469201-Risk Factors, pubmed-meshheading:21469201-Transcription Factors
pubmed:year
2011
pubmed:articleTitle
Variants in estrogen-related genes and risk of Parkinson's disease.
pubmed:affiliation
Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural