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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2011-6-23
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pubmed:abstractText |
Inflammatory lesions in the central nervous system of patients with neuromyelitis optica are characterized by infiltration of T cells and deposition of aquaporin-4-specific antibodies and complement on astrocytes at the glia limitans. Although the contribution of aquaporin-4-specific autoantibodies to the disease process has been recently elucidated, a potential role of aquaporin-4-specific T cells in lesion formation is unresolved. To address this issue, we raised aquaporin-4-specific T cell lines in Lewis rats and characterized their pathogenic potential in the presence and absence of aquaporin-4-specific autoantibodies of neuromyelitis optica patients. We show that aquaporin-4-specific T cells induce brain inflammation with particular targeting of the astrocytic glia limitans and permit the entry of pathogenic anti-aquaporin-4-specific antibodies to induce NMO-like lesions in spinal cord and brain. In addition, transfer of aquaporin-4-specific T cells provoked mild (subclinical) myositis and interstitial nephritis. We further show that the expression of the conformational epitope, recognized by NMO patient-derived aquaporin-4-specific antibodies is induced in kidney cells by the pro-inflammatory cytokine gamma-interferon. Our data provide further support for the view that NMO lesions may be induced by a complex interplay of T cell mediated and humoral immune responses against aquaporin-4.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21468722-11371357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21468722-11812640,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1432-0533
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pubmed:author |
pubmed-author:BradlMonikaM,
pubmed-author:FischerMarie-ThereseMT,
pubmed-author:FujiharaKazuoK,
pubmed-author:KiticMajaM,
pubmed-author:LassmannHansH,
pubmed-author:MaderSimoneS,
pubmed-author:MisuTatsuroT,
pubmed-author:PohlMariaM,
pubmed-author:ReindlMarkusM,
pubmed-author:SchandaKathrinK,
pubmed-author:SharmaRakhiR,
pubmed-author:WimmerIsabellaI
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pubmed:issnType |
Electronic
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pubmed:volume |
122
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
21-34
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pubmed:meshHeading |
pubmed-meshheading:21468722-Animals,
pubmed-meshheading:21468722-Aquaporin 4,
pubmed-meshheading:21468722-Astrocytes,
pubmed-meshheading:21468722-Autoantibodies,
pubmed-meshheading:21468722-Cell Line,
pubmed-meshheading:21468722-Cells, Cultured,
pubmed-meshheading:21468722-Disease Models, Animal,
pubmed-meshheading:21468722-Encephalomyelitis,
pubmed-meshheading:21468722-Epitopes,
pubmed-meshheading:21468722-Humans,
pubmed-meshheading:21468722-Immunoglobulin G,
pubmed-meshheading:21468722-Interferon-gamma,
pubmed-meshheading:21468722-Kidney,
pubmed-meshheading:21468722-Neuroglia,
pubmed-meshheading:21468722-Neuromyelitis Optica,
pubmed-meshheading:21468722-Rats,
pubmed-meshheading:21468722-Rats, Inbred Lew,
pubmed-meshheading:21468722-T-Lymphocytes
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pubmed:year |
2011
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pubmed:articleTitle |
Pathogenic T cell responses against aquaporin 4.
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pubmed:affiliation |
Department of Neuroimmunology, Center for Brain Research, Medical University Vienna, Spitalgasse 4, 1090 Vienna, Austria.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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