Linked Life Data

21468611

Source:http://linkedlifedata.com/resource/pubmed/id/21468611

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2011-4-6
pubmed:abstractText
Hemoglobin (Hb) Ottawa [?15 (A13) Gly?Arg], also known as Hb Siam, was first described in an 82-year-old Canadian in 1974. The same year, a second case was reported in a 28-year-old Chinese male living in Thailand. A third case was found in 1986 in a Chinese female living in the Hubei province of China. Since then, there have been no reports of Hb Ottawa in mainland China in the English literature. Hb Ottawa results from a GGT?CGT mutation in codon 15 of the ?1 or ?2-globin gene. Hb Ottawa carriers do not present any clinical symptoms or hematological changes, and are often diagnosed during a health examination and thalassemia screening. In a hemoglobin survey of 9745 students in Chaozhou, Guangdong, China, we identified four cases of Hb Ottawa in a thalassemia screening by Hb electrophoresis, and confirmed it to be the result of a GGT?CGT mutation in codon 15 of the ?2-globin gene by DNA sequence analysis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1791-3004
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
581-3
pubmed:meshHeading
pubmed:articleTitle
Molecular and clinical characteristics of hemoglobin Ottawa detected in a Chinese population.
pubmed:affiliation
Department of Central Laboratory, Chaozhou Central Hospital, Chaozhou, Guangdong 521021, PR China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't