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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-7-19
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pubmed:abstractText |
To control the activity of photosensitized singlet oxygen ((1)O(2)) generation, the electron donor-connecting porphyrin, 5-(9'-anthryl)-10,15,20-tris(p-pyridyl)porphyrin (AnTPyP), was designed and synthesized. AnTPyP became water-soluble by the protonation of the pyridyl moieties in the presence of 5 mM trifluoroacetic acid (pH 2.3). The photoexcited state of the porphyrin ring in an AnTPyP molecule was effectively deactivated by intramolecular electron transfer from the anthracene moiety within 0.04 ns in an aqueous solution. The deactivation was suppressed by the interaction with a DNA strand, resulting in the elongation of the lifetime of the porphyrin excited state and the enhancement of the fluorescence intensity. Furthermore, it was confirmed that the interaction enabled the photoexcited AnTPyP to generate (1)O(2). Selective (1)O(2) generation by forming a complex with DNA should be the initial step to realize the target selective photodynamic therapy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1751-1097
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pubmed:author |
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pubmed:copyrightInfo |
© 2011 The Authors. Photochemistry and Photobiology © 2011 The American Society of Photobiology.
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pubmed:issnType |
Electronic
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
833-9
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pubmed:meshHeading |
pubmed-meshheading:21466558-Anthracenes,
pubmed-meshheading:21466558-Antineoplastic Agents,
pubmed-meshheading:21466558-DNA,
pubmed-meshheading:21466558-Electron Transport,
pubmed-meshheading:21466558-Fluorescence,
pubmed-meshheading:21466558-Humans,
pubmed-meshheading:21466558-Light,
pubmed-meshheading:21466558-Models, Molecular,
pubmed-meshheading:21466558-Neoplasms,
pubmed-meshheading:21466558-Oligonucleotides,
pubmed-meshheading:21466558-Oxidation-Reduction,
pubmed-meshheading:21466558-Photochemistry,
pubmed-meshheading:21466558-Photochemotherapy,
pubmed-meshheading:21466558-Photosensitizing Agents,
pubmed-meshheading:21466558-Porphyrins,
pubmed-meshheading:21466558-Singlet Oxygen,
pubmed-meshheading:21466558-Spectrometry, Fluorescence,
pubmed-meshheading:21466558-Trifluoroacetic Acid
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pubmed:articleTitle |
Control of singlet oxygen generation photosensitized by meso-anthrylporphyrin through interaction with DNA.
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pubmed:affiliation |
Department of Basic Engineering (Chemistry), Faculty of Engineering, Shizuoka University, Shizuoka, Japan. tkhirak@ipc.shizuoka.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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