Linked Life Data

21465628

Source:http://linkedlifedata.com/resource/pubmed/id/21465628

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2011-4-11
pubmed:abstractText
Recently, the rapid emergence of microbial pathogens which are resistant to currently available antibiotics has triggered considerable interest searching for naturally occuring antimicrobial peptides (AMPs). Because AMPs from food organisms are comparatively nontoxic, a number of them are used as sources, purified in new antibiotics. Herein, an antibacterial peptide (heat-stable KPS-1) was isolated from Korean pen shell (Atrina pectinata) by the following procedures: solvent-extraction, heating, ultrafiltration, and RP-HPLC. The molecular weight of KPS-1 (4549.1 Da) was revealed by MALDI-TOF/MS analysis. Interestingly, KPS-1 inhibited in vitro growth of Gram-negative bacteria, including Escherichia coli, E. coli O157, Pseudomonas aeruginosa, Enterobacter sakazakii, and Salmonella typhimurium, at pH 5.2, rather than at pH 7.2. Its minimal inhibitory concentrations (MICs) were ranged from 20 to 80 µg/ml; however, it was not effective against human red blood cells at a concentration of 500 µg/ml. This suggests that this peptide is useful as a clinical agent for some human organs in an acidic environment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1099-1387
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 European Peptide Society and John Wiley & Sons, Ltd.
pubmed:issnType
Electronic
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
353-7
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Effect of acidic pH on antibacterial action of peptide isolated from Korean pen shell (Atrina pectinata).
pubmed:affiliation
Department of Biotechnology, Chosun University, Gwangju, Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't