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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-4-5
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pubmed:abstractText |
Mitochondrial dysfunction induces insulin resistance in myocytes via a reduction of insulin receptor substrate-1 (IRS-1) expression. However, the effect of mitochondrial dysfunction on insulin sensitivity is not understood well in hepatocytes. Although research has implicated the translational repression of target genes by endogenous non-coding microRNAs (miRNA) in the pathogenesis of various diseases, the identity and role of the miRNAs that are involved in the development of insulin resistance also remain largely unknown.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e17343
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pubmed:dateRevised |
2011-8-17
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pubmed:meshHeading |
pubmed-meshheading:21464990-3' Untranslated Regions,
pubmed-meshheading:21464990-Base Sequence,
pubmed-meshheading:21464990-DNA, Mitochondrial,
pubmed-meshheading:21464990-Ethidium,
pubmed-meshheading:21464990-Gene Expression Regulation,
pubmed-meshheading:21464990-Hepatocytes,
pubmed-meshheading:21464990-Humans,
pubmed-meshheading:21464990-Insulin Receptor Substrate Proteins,
pubmed-meshheading:21464990-Insulin Resistance,
pubmed-meshheading:21464990-MicroRNAs,
pubmed-meshheading:21464990-Mitochondria,
pubmed-meshheading:21464990-Molecular Sequence Data,
pubmed-meshheading:21464990-Protein Binding,
pubmed-meshheading:21464990-Signal Transduction,
pubmed-meshheading:21464990-Transcription, Genetic
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pubmed:year |
2011
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pubmed:articleTitle |
The induction of microRNA targeting IRS-1 is involved in the development of insulin resistance under conditions of mitochondrial dysfunction in hepatocytes.
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pubmed:affiliation |
Department of Biochemistry, Dongguk University College of Medicine, Kyungju, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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