Linked Life Data

21464822

Source:http://linkedlifedata.com/resource/pubmed/id/21464822

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pubmed-article:21464822pubmed:abstractTextAccumulating evidence indicates that mitochondria have a key role in non-alcoholic fatty liver disease (NAFLD). C57BL/6J mice were fed a choline-deficient, ethionine-supplemented (CDE) diet. Histological studies demonstrated accumulation of fat vacuoles in up to 90% of hepatocytes in mice fed the CDE diet for 14 days. In addition, a decrease in mitochondrial levels, together with an increase in superoxide radicals' levels were observed, indicating elevation of oxidative stress in hepatocytes. ATP levels were decreased in livers from CDE-fed mice after overnight fasting. This was accompanied by a compensative and significant increase in peroxisome-proliferator-activated receptor-? coactivator 1? (PGC1?) mRNA levels in comparison to control livers. However, there was a reduction in PGC1? protein levels in CDE-treated mice. Moreover, the expression of mitochondrial biogenesis genes nuclear respiratory factor 1 (NRF-1), mitochondrial transcription factor A (TFAM), mitochondrial transcription factor B1 (TFB1M) and mitochondrial transcription factor B2 (TFB2M), which are all regulated by PGC1? activity, remained unchanged in fasted CDE-treated mice. These results indicate impaired activity of PGC1?. The impaired activity was further confirmed by chromatin immunoprecipitation analysis, which demonstrated decreased interaction of PGC1? with promoters containing NRF-1 and NRF-2 response elements in mice fed the CDE diet. A decrease in PGC1? ability to activate the expression of the gluconeogenic gene phosphoenol-pyruvate carboxykinase was also observed. This study demonstrates, for the first time, that attenuated mitochondrial biogenesis in steatotic livers is associated with impaired biological activity of PGC1?.lld:pubmed
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pubmed-article:21464822pubmed:year2011lld:pubmed
pubmed-article:21464822pubmed:articleTitleFatty liver is associated with impaired activity of PPAR?-coactivator 1? (PGC1?) and mitochondrial biogenesis in mice.lld:pubmed
pubmed-article:21464822pubmed:affiliationThe School of Nutritional Sciences, Institute of Biochemistry, Food Science and Nutrition, The Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.lld:pubmed
pubmed-article:21464822pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21464822pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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