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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1990-12-13
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pubmed:abstractText |
Endoscopic photodynamic therapy (PDT) with haematoporphyrin derivative was used in the primary treatment of 69 patients with inoperable gastrointestinal neoplasms. Patients were divided into three groups: 31 with oesophageal squamous cell carcinoma, 17 with adenocarcinoma of the stomach or lower third of the oesophagus and 21 with rectosigmoid adenocarcinoma. After infusion of 2.5-5.0 mg haematoporphyrin derivative per kilogram of body weight, lesions were irradiated using an argon dye laser (632 nm). During a follow-up period averaging 20 months (27.9 months for 35 surviving patients), complete local tumour destruction and negative histology were observed in 32 out of 69 cases. Flow-cytometric analysis of DNA content before and after PDT suggests that a clonal selection occurs in some cases of treatment failure. The results of this open pilot study suggest the potential efficacy of PDT as a curative treatment for selected cases of inoperable gastrointestinal cancers.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1011-1344
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
157-65
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pubmed:dateRevised |
2007-7-23
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pubmed:meshHeading |
pubmed-meshheading:2146376-Adenocarcinoma,
pubmed-meshheading:2146376-Aged,
pubmed-meshheading:2146376-Antineoplastic Agents,
pubmed-meshheading:2146376-Carcinoma, Squamous Cell,
pubmed-meshheading:2146376-DNA, Neoplasm,
pubmed-meshheading:2146376-Endoscopy,
pubmed-meshheading:2146376-Esophageal Neoplasms,
pubmed-meshheading:2146376-Female,
pubmed-meshheading:2146376-Follow-Up Studies,
pubmed-meshheading:2146376-Gastrointestinal Neoplasms,
pubmed-meshheading:2146376-Hematoporphyrin Derivative,
pubmed-meshheading:2146376-Hematoporphyrins,
pubmed-meshheading:2146376-Humans,
pubmed-meshheading:2146376-Male,
pubmed-meshheading:2146376-Middle Aged,
pubmed-meshheading:2146376-Photochemotherapy,
pubmed-meshheading:2146376-Radiation-Sensitizing Agents,
pubmed-meshheading:2146376-Rectal Neoplasms,
pubmed-meshheading:2146376-Sigmoid Neoplasms,
pubmed-meshheading:2146376-Stomach Neoplasms
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pubmed:year |
1990
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pubmed:articleTitle |
Endoscopic photodynamic therapy with haematoporphyrin derivative in gastroenterology.
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pubmed:affiliation |
Laser Department, Hôpital Guillaume et René Laënnec, Nantes, France.
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pubmed:publicationType |
Journal Article
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