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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2011-4-27
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pubmed:abstractText |
D-serine (D-Ser) is an endogenous co-agonist for NMDA receptors and regulates neurotransmission and synaptic plasticity in the forebrain. D-Ser is also found in the cerebellum during the early postnatal period. Although D-Ser binds to the ?2 glutamate receptor (GluD2, Grid2) in vitro, its physiological significance has remained unclear. Here we show that D-Ser serves as an endogenous ligand for GluD2 to regulate long-term depression (LTD) at synapses between parallel fibers and Purkinje cells in the immature cerebellum. D-Ser was released mainly from Bergmann glia after the burst stimulation of parallel fibers in immature, but not mature, cerebellum. D-Ser rapidly induced endocytosis of AMPA receptors and mutually occluded LTD in wild-type, but not Grid2-null, Purkinje cells. Moreover, mice expressing mutant GluD2 in which the binding site for D-Ser was disrupted showed impaired LTD and motor dyscoordination during development. These results indicate that glial D-Ser regulates synaptic plasticity and cerebellar functions by interacting with GluD2.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-amino-5-phosphopentanoic acid,
http://linkedlifedata.com/resource/pubmed/chemical/D-Amino-Acid Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Dao1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Glycine Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoglycerate Dehydrogenase,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Glutamate,
http://linkedlifedata.com/resource/pubmed/chemical/Serine,
http://linkedlifedata.com/resource/pubmed/chemical/Strychnine,
http://linkedlifedata.com/resource/pubmed/chemical/Valine,
http://linkedlifedata.com/resource/pubmed/chemical/glutamate receptor delta 2
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1546-1726
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pubmed:author |
pubmed-author:EmiKyoichiK,
pubmed-author:KakegawaWataruW,
pubmed-author:KohdaKazuhisaK,
pubmed-author:KonnoRyuichiR,
pubmed-author:MatsudaKeikoK,
pubmed-author:MatsudaShinjiS,
pubmed-author:MiyoshiYurikaY,
pubmed-author:MotohashiJunkoJ,
pubmed-author:VINCENZILL,
pubmed-author:YuzakiMichisukeM,
pubmed-author:ZaitsuKiyoshiK
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pubmed:issnType |
Electronic
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
603-11
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pubmed:meshHeading |
pubmed-meshheading:21460832-Analysis of Variance,
pubmed-meshheading:21460832-Animals,
pubmed-meshheading:21460832-Animals, Newborn,
pubmed-meshheading:21460832-Biophysics,
pubmed-meshheading:21460832-Cells, Cultured,
pubmed-meshheading:21460832-Cerebellum,
pubmed-meshheading:21460832-Chromatography, High Pressure Liquid,
pubmed-meshheading:21460832-D-Amino-Acid Oxidase,
pubmed-meshheading:21460832-Electric Stimulation,
pubmed-meshheading:21460832-Excitatory Amino Acid Antagonists,
pubmed-meshheading:21460832-Excitatory Postsynaptic Potentials,
pubmed-meshheading:21460832-Glycine Agents,
pubmed-meshheading:21460832-Green Fluorescent Proteins,
pubmed-meshheading:21460832-Long-Term Synaptic Depression,
pubmed-meshheading:21460832-Mice,
pubmed-meshheading:21460832-Mice, Transgenic,
pubmed-meshheading:21460832-Microdialysis,
pubmed-meshheading:21460832-Mutation,
pubmed-meshheading:21460832-Patch-Clamp Techniques,
pubmed-meshheading:21460832-Phosphoglycerate Dehydrogenase,
pubmed-meshheading:21460832-Psychomotor Performance,
pubmed-meshheading:21460832-Purkinje Cells,
pubmed-meshheading:21460832-Receptors, Glutamate,
pubmed-meshheading:21460832-Rotarod Performance Test,
pubmed-meshheading:21460832-Serine,
pubmed-meshheading:21460832-Statistics, Nonparametric,
pubmed-meshheading:21460832-Strychnine,
pubmed-meshheading:21460832-Valine
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pubmed:year |
2011
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pubmed:articleTitle |
D-serine regulates cerebellar LTD and motor coordination through the ?2 glutamate receptor.
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pubmed:affiliation |
Department of Physiology, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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