21459796

Source:http://linkedlifedata.com/resource/pubmed/id/21459796

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0006826, umls-concept:C0030705, umls-concept:C0205179, umls-concept:C0205208, umls-concept:C0205369, umls-concept:C0679932, umls-concept:C0920321, umls-concept:C1579259, umls-concept:C1999216
pubmed:issue	10
pubmed:dateCreated	2011-5-17
pubmed:databankReference	http://linkedlifedata.com/resource/pubmed/xref/ClinicalTrials.gov/NCT00536835
pubmed:abstractText	GSK461364 is an ATP-competitive inhibitor of polo-like kinase 1 (Plk1). A phase I study of two schedules of intravenous GSK461364 was conducted.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9502500
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, http://linkedlifedata.com/resource/pubmed/chemical/Benzimidazoles, http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins, http://linkedlifedata.com/resource/pubmed/chemical/GSK 461364A, http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Thiophenes, http://linkedlifedata.com/resource/pubmed/chemical/polo-like kinase 1
pubmed:status	MEDLINE
pubmed:month	May
pubmed:issn	1078-0432
pubmed:author	pubmed-author:AllredAlicia JAJ, pubmed-author:BarkerDouglasD, pubmed-author:BarriusoJorgeJ, pubmed-author:BlagdenSarah PSP, pubmed-author:BrunettoAndre TAT, pubmed-author:DarMohammed MMM, pubmed-author:DegenhardtYan YYY, pubmed-author:LampkinThomas ATA, pubmed-author:MedaniHanineH, pubmed-author:MurraySharon CSC, pubmed-author:OlmosDavidD, pubmed-author:SharmaRohiniR, pubmed-author:SmithDeborah ADA, pubmed-author:TaegtmeyerAnne BAB, pubmed-author:WilsonRichardR, pubmed-author:YapTimothy ATA, pubmed-author:de BonoJohann SJS
pubmed:copyrightInfo	©2011 AACR.
pubmed:issnType	Print
pubmed:day	15
pubmed:volume	17
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	3420-30
pubmed:dateRevised	2011-11-2
pubmed:meshHeading	pubmed-meshheading:21459796-Adenocarcinoma, pubmed-meshheading:21459796-Adult, pubmed-meshheading:21459796-Aged, pubmed-meshheading:21459796-Aged, 80 and over, pubmed-meshheading:21459796-Antineoplastic Agents, pubmed-meshheading:21459796-Benzimidazoles, pubmed-meshheading:21459796-Binding, Competitive, pubmed-meshheading:21459796-Cell Cycle Proteins, pubmed-meshheading:21459796-Colorectal Neoplasms, pubmed-meshheading:21459796-Disease Progression, pubmed-meshheading:21459796-Female, pubmed-meshheading:21459796-Humans, pubmed-meshheading:21459796-Male, pubmed-meshheading:21459796-Maximum Tolerated Dose, pubmed-meshheading:21459796-Middle Aged, pubmed-meshheading:21459796-Neoplasms, pubmed-meshheading:21459796-Protein Kinase Inhibitors, pubmed-meshheading:21459796-Protein-Serine-Threonine Kinases, pubmed-meshheading:21459796-Proto-Oncogene Proteins, pubmed-meshheading:21459796-Substrate Specificity, pubmed-meshheading:21459796-Thiophenes
pubmed:year	2011
pubmed:articleTitle	Phase I study of GSK461364, a specific and competitive Polo-like kinase 1 inhibitor, in patients with advanced solid malignancies.
pubmed:affiliation	Drug Development Unit, Royal Marsden NHS Foundation Trust and Institute of Cancer Research, Downs Road, Sutton, Surrey, United Kingdom.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't, Multicenter Study, Clinical Trial, Phase I