Source:http://linkedlifedata.com/resource/pubmed/id/21459575
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
2011-5-2
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pubmed:abstractText |
2,2'-Diphenyl-3,3'-diindolylethylene (DPDIE) derivatives 3a-g were regioselectively prepared in one pot from indoles 1a-g in the presence of Lewis acids and were subsequently evaluated for cytotoxic activity against human leukemic cell lines, U937 and K562. The most potent compound 3g exhibited IC(50) of 13.0-17.0 ?M.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1464-3405
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pubmed:author | |
pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3084-7
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pubmed:meshHeading |
pubmed-meshheading:21459575-Antineoplastic Agents,
pubmed-meshheading:21459575-Cell Line, Tumor,
pubmed-meshheading:21459575-Cell Survival,
pubmed-meshheading:21459575-Crystallography, X-Ray,
pubmed-meshheading:21459575-Ethylenes,
pubmed-meshheading:21459575-Flow Cytometry,
pubmed-meshheading:21459575-Humans,
pubmed-meshheading:21459575-Indoles,
pubmed-meshheading:21459575-Inhibitory Concentration 50,
pubmed-meshheading:21459575-Molecular Structure
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pubmed:year |
2011
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pubmed:articleTitle |
Regioselective one pot synthesis of 3,3'-diindolylethylene derivatives and study of their cytotoxic activity.
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pubmed:affiliation |
Department of Chemistry, Indian Institute of Chemical Biology (Unit of C.S.I.R), 4, Raja S.C. Mullick Road, Jadavpur, Kolkata 700 032, India.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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