Linked Life Data

21458555

Source:http://linkedlifedata.com/resource/pubmed/id/21458555

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-5-9
pubmed:abstractText
Garcinia kola is regarded as an antidote and anti-hepatotoxic agent. We examined its protection ability against mercury (Hg), lead (Pb) and cadmium (Cd) accumulation in the liver. The ground seed was mixed with rat feed (5%, w/w) and fed to rats while Hg (10 ppm), Cd (200 ppm) and Pb (100 ppm) was given in drinking water. Garcinia kola was administered either at the same time with the metals (group 2), a week after exposure to heavy metals (group 3) or given a week before heavy metal exposure (group 4) for six weeks. The heavy metal accumulations in the liver were determined using AAS. Garcinia kola could not reverse the weight reduction in the heavy metal exposed groups although it offers more protection and aid greater elimination of heavy metals from the liver. There was a significant (P<0.01) increase in protection by Garcinia kola to Cd (72.4%) and Pb (56.2%) accumulation when compared to Hg (40%) at week 2 which was significantly (P<0.01) decreased at week 4 when compared to week 2. At week 6, the percentage protection to both Hg (64.2%) and Cd (62.2%) were comparable to each other while protection to Pb (49.9%) accumulation was significantly (P<0.01) reduced. The percentage protection was time-dependent in some groups but treatment during and after the exposure provided a greater protection. Garcinia kola has the highest hepatoprotective effect to Cd followed by Hg and least protection against Pb toxicity in rats and its administration is beneficial in reducing heavy metal accumulation in the liver.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1872-7573
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
17
pubmed:volume
135
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
488-91
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Comparative study on the efficacy of Garcinia kola in reducing some heavy metal accumulation in liver of Wistar rats.
pubmed:affiliation
Department of Basic Medical Sciences, University of the West Indies, Mona Campus, Kingston 7, Jamaica. chukwuemeka.nwokocha@uwimona.edu.jm
pubmed:publicationType
Journal Article, Comparative Study