Linked Life Data

21458500

Source:http://linkedlifedata.com/resource/pubmed/id/21458500

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2011-5-16
pubmed:abstractText
Impairments in attention/vigilance and response disinhibition are commonly observed in several neuropsychiatric disorders. Validating animal models could help in developing therapeutics for cognitive deficits and improving functional outcomes in such disorders. The 5-choice continuous performance test (5C-CPT) in mice offers the opportunity to assess vigilance and two forms of impulsivity. Since reduced dopamine D4 receptor (DRD4) function is implicated in several disorders, DRD4 is a potential therapeutic target for cognition enhancement. We trained wildtype (WT), heterozygous (HT), and knockout (KO) mice of the murine Drd4 to perform the 5C-CPT under baseline and variable stimulus duration conditions. To dissect motor impulsivity (premature responding) from behavioral disinhibition (false alarms), we administered the 5-HT(2C) antagonist SB242084 during an extended inter-trial-interval session. We also examined the preattentive and exploratory profile of these mice in prepulse inhibition (PPI) and the Behavioral Pattern Monitor (BPM). Reduced Drd4 expression in HT mice, as confirmed by quantitative RT-PCR, resulted in response disinhibition and impaired 5C-CPT performance, while premature responding was unaffected. Conversely, SB242084 increased premature responding without affecting response inhibition or attentional measures. No genotypic differences were observed in PPI or BPM behavior. Thus, reduced Drd4 expression impairs attentional performance, but not other behaviors associated with neuropsychiatric disorders. Moreover, the use of signal and non-signal stimuli in the 5C-CPT enabled the differentiation of response disinhibition from motor impulsivity in a vigilance task.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1872-7549
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
12
pubmed:volume
222
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
183-92
pubmed:meshHeading
pubmed-meshheading:21458500-Aminopyridines, pubmed-meshheading:21458500-Analysis of Variance, pubmed-meshheading:21458500-Animals, pubmed-meshheading:21458500-Arousal, pubmed-meshheading:21458500-Attention, pubmed-meshheading:21458500-Choice Behavior, pubmed-meshheading:21458500-Dose-Response Relationship, Drug, pubmed-meshheading:21458500-Exploratory Behavior, pubmed-meshheading:21458500-Gene Expression, pubmed-meshheading:21458500-Genotype, pubmed-meshheading:21458500-Indoles, pubmed-meshheading:21458500-Inhibition (Psychology), pubmed-meshheading:21458500-Mice, pubmed-meshheading:21458500-Mice, Inbred C57BL, pubmed-meshheading:21458500-Mice, Knockout, pubmed-meshheading:21458500-Motor Activity, pubmed-meshheading:21458500-Neuropsychological Tests, pubmed-meshheading:21458500-RNA, Messenger, pubmed-meshheading:21458500-Reaction Time, pubmed-meshheading:21458500-Receptors, Dopamine D4, pubmed-meshheading:21458500-Sensory Gating, pubmed-meshheading:21458500-Serotonin Antagonists, pubmed-meshheading:21458500-Startle Reaction, pubmed-meshheading:21458500-Statistics as Topic, pubmed-meshheading:21458500-Time Factors
pubmed:year
2011
pubmed:articleTitle
The effect of reduced dopamine D4 receptor expression in the 5-choice continuous performance task: Separating response inhibition from premature responding.
pubmed:affiliation
Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0804, United States. jaredyoung@ucsd.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural