rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-4-18
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pubmed:abstractText |
The human papillomavirus type 8 (HPV8) is associated with the development of non-melanoma skin cancer. Transgenic mice expressing the complete early gene region of HPV8 (E6/E7/E1/E2/E4=CER) or E6 separately under the control of the keratin14 promoter spontaneously developed papillomas characterized by varying degrees of epidermal dysplasia. Papilloma growth could be synchronized by a single UVA/B irradiation of the skin, which led to the development of papillomas within three weeks.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
May
|
pubmed:issn |
1873-569X
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pubmed:author |
|
pubmed:copyrightInfo |
Copyright © 2011 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
62
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
84-90
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pubmed:meshHeading |
pubmed-meshheading:21458245-Animals,
pubmed-meshheading:21458245-Betapapillomavirus,
pubmed-meshheading:21458245-Cornified Envelope Proline-Rich Proteins,
pubmed-meshheading:21458245-Cystatin A,
pubmed-meshheading:21458245-Gene Expression Profiling,
pubmed-meshheading:21458245-Gene Expression Regulation,
pubmed-meshheading:21458245-Immunohistochemistry,
pubmed-meshheading:21458245-Keratin-14,
pubmed-meshheading:21458245-Mice,
pubmed-meshheading:21458245-Mice, Transgenic,
pubmed-meshheading:21458245-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:21458245-Papilloma,
pubmed-meshheading:21458245-Promoter Regions, Genetic,
pubmed-meshheading:21458245-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21458245-Skin,
pubmed-meshheading:21458245-Tissue Distribution
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pubmed:year |
2011
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pubmed:articleTitle |
Enhanced StefinA and Sprr2 expression during papilloma formation in HPV8 transgenic mice.
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pubmed:affiliation |
Institute of Virology, University of Cologne, Fürst-Pückler-Str. 56, 50935 Cologne, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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