Linked Life Data

21455956

Source:http://linkedlifedata.com/resource/pubmed/id/21455956

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2011-4-15
pubmed:abstractText
Sympathetic regulation plays an important role in fetal survival and development during early pregnancy. Maternal adaptations to pregnancy may involve changes of the spleen in its structure, size, and function. This study was therefore designed to investigate the effects of sympathetic nerves on these adaptations in the maternal spleen of mice during early pregnancy. The adult female mice were intraperitoneally injected with neurotoxin 6-hydroxydopamine (6-OHDA) for 5 consecutive days to selectively destroy the sympathetic nerves. The results were as follows: (1) the splenic weight was reduced in the 6-OHDA group by 10.9%-13.0% at E5-E9 (P < 0.05) when compared with the control group. (2) The splenic nodule and periarterial lymphatic sheath of the 6-OHDA-treated mice were smaller than those of control mice. The proliferating cell nuclear antigen positive cells of 6-OHDA-treated group were decreased by 10.9%-16.2% (P < 0.05) at E1-E9. (3) Lymphocyte proliferation indices in response to concanavalin A or lipopolysaccharide were significantly decreased (P < 0.05) in the 6-OHDA group. (4) When compared with control mice, the superoxide dismutase and glutathione peroxidase activities of 6-OHDA-treated mice were decreased by 14.3%-21.9% (P < 0.05) at E1-E9 and 17.4%-25.0% (P < 0.05) at E3-E9, respectively. In contrast, the malondialdehyde content of 6-OHDA group was increased by 10.6%-38.6% (P < 0.05) at E3-E9. The results demonstrated the regulation of pregnancy-dependent adaptations in the spleen through the sympathetic nerve activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1932-8494
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Wiley-Liss, Inc.
pubmed:issnType
Electronic
pubmed:volume
294
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
875-82
pubmed:meshHeading
pubmed-meshheading:21455956-Animals, pubmed-meshheading:21455956-Antioxidants, pubmed-meshheading:21455956-Concanavalin A, pubmed-meshheading:21455956-Female, pubmed-meshheading:21455956-Glutathione Peroxidase, pubmed-meshheading:21455956-Hydroxydopamines, pubmed-meshheading:21455956-Lipid Peroxidation, pubmed-meshheading:21455956-Lipopolysaccharides, pubmed-meshheading:21455956-Lymphocyte Activation, pubmed-meshheading:21455956-Lymphocytes, pubmed-meshheading:21455956-Male, pubmed-meshheading:21455956-Malondialdehyde, pubmed-meshheading:21455956-Mice, pubmed-meshheading:21455956-Organ Size, pubmed-meshheading:21455956-Oxidants, pubmed-meshheading:21455956-Pregnancy, pubmed-meshheading:21455956-Pregnancy, Animal, pubmed-meshheading:21455956-Prenatal Exposure Delayed Effects, pubmed-meshheading:21455956-Proliferating Cell Nuclear Antigen, pubmed-meshheading:21455956-Spleen, pubmed-meshheading:21455956-Sympathetic Nervous System
pubmed:year
2011
pubmed:articleTitle
Effect of sympathetic nerves on proliferation of splenic lymphocytes and antioxidant function of maternal spleen in early pregnant mice.
pubmed:affiliation
Laboratory of Anatomy of Domestic Animal, Department of Basic Veterinary Sciences, College of Veterinary Medicine, China Agricultural University, Haidian, Beijing, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't