Linked Life Data

21454516

Source:http://linkedlifedata.com/resource/pubmed/id/21454516

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
20
pubmed:dateCreated
2011-5-16
pubmed:abstractText
Anterior Gradient Homolog 2 (AGR2) is expressed by the normal intestine and by most human adenocarcinomas, including those derived from the esophagus, pancreas, lung, breast, ovary, and prostate. Xenografts of human adenocarcinoma cell lines in nude mice previously demonstrated that AGR2 supports tumor growth. In addition, AGR2 is able to induce in vitro a transformed phenotype in fibroblast and epithelial cell lines. The mechanism underlying the growth promoting effects of AGR2 is unknown. The present study shows that AGR2 induces expression of amphiregulin (AREG), a growth promoting EGFR ligand. Induced AREG expression in adenocarcinoma cells is able to rescue the transformed phenotype that is lost when AGR2 expression is reduced. Additional experiments demonstrate that AGR2 induction of AREG is mediated by activation of the Hippo signaling pathway co-activator, YAP1. Thus AGR2 promotes growth by regulating the Hippo and EGF receptor signaling pathways.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1083-351X
pubmed:author
pubmed:copyrightInfo
© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.
pubmed:issnType
Electronic
pubmed:day
20
pubmed:volume
286
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
18301-10
pubmed:meshHeading
pubmed-meshheading:21454516-Adaptor Proteins, Signal Transducing, pubmed-meshheading:21454516-Adenocarcinoma, pubmed-meshheading:21454516-Animals, pubmed-meshheading:21454516-Cell Line, Tumor, pubmed-meshheading:21454516-Gene Expression Regulation, Neoplastic, pubmed-meshheading:21454516-Glycoproteins, pubmed-meshheading:21454516-Humans, pubmed-meshheading:21454516-Intercellular Signaling Peptides and Proteins, pubmed-meshheading:21454516-Mice, pubmed-meshheading:21454516-Mice, Nude, pubmed-meshheading:21454516-Neoplasm Proteins, pubmed-meshheading:21454516-Neoplasm Transplantation, pubmed-meshheading:21454516-Phosphoproteins, pubmed-meshheading:21454516-Proteins, pubmed-meshheading:21454516-Receptor, Epidermal Growth Factor, pubmed-meshheading:21454516-Signal Transduction, pubmed-meshheading:21454516-Transplantation, Heterologous
pubmed:year
2011
pubmed:articleTitle
The human adenocarcinoma-associated gene, AGR2, induces expression of amphiregulin through Hippo pathway co-activator YAP1 activation.
pubmed:affiliation
Department of Medicine, Stanford University, Stanford, California 94305, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural