Linked Life Data

21454292

Source:http://linkedlifedata.com/resource/pubmed/id/21454292

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-4-1
pubmed:abstractText
Daily patterns of animal behavior are potentially of vast functional importance. Fitness benefits have been identified in nature by the association between individual timing and survival or by the fate of individuals after experimental deletion of their circadian pacemaker. The recent advances in unraveling the molecular basis of circadian timing enable new approaches to natural selection on timing. The investigators report on the effect and fate of the mutant Per2(Brdm1) allele in 4 replicate populations of house mice in a seminatural outside environment over 2 years. This allele is known to compromise circadian organization and entrainment and to cause multiple physiological disturbances. Mice (N=250) bred from Per2(Brdm1) heterozygotes were implanted subcutaneously with transponders and released in approximately Mendelian ratios in four 400 m(2) pens. An electronic system stored the times of all visits to feeders of each individual. The study first demonstrates that mice are not explicitly nocturnal in this natural environment. Feeding activity was predominantly and sometimes exclusively diurnal and spread nearly equally over day and night under the protective snow cover in winter. The effect of Per2(Brdm1) on activity timing is negligible compared to seasonal changes in all genotypes. Second, the Per2(Brdm1) allele did not have persistent negative effects on fitness. In the first year, the allele gradually became less frequent by reducing survival. New cohorts captured had the same Per2(Brdm1) frequency as the survivors from previous cohorts, consistent with an absence of an effect on reproduction. In the second year, the allele recovered to about its initial frequency (0.54). These changes in selective advantage were primarily due to female mice, as females lived longer and the sex ratio dropped to about 25% males in the population. While it is unknown which selective advantage led to the recovery, the results caution against inferences from laboratory experiments on fitness consequences in the natural environment. It also demonstrates that the activity of mice, while strictly nocturnal in the laboratory, may be partially or completely diurnal in the field. The new method allows assessment of natural selection on specific alleles on a day-today basis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1552-4531
pubmed:author
pubmed:copyrightInfo
© 2011 Sage Publications
pubmed:issnType
Electronic
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
118-29
pubmed:meshHeading
pubmed-meshheading:21454292-Alleles, pubmed-meshheading:21454292-Animals, pubmed-meshheading:21454292-Behavior, Animal, pubmed-meshheading:21454292-Chronobiology Disorders, pubmed-meshheading:21454292-Circadian Clocks, pubmed-meshheading:21454292-Circadian Rhythm, pubmed-meshheading:21454292-Feeding Behavior, pubmed-meshheading:21454292-Female, pubmed-meshheading:21454292-Gene Frequency, pubmed-meshheading:21454292-Genetic Fitness, pubmed-meshheading:21454292-Individuality, pubmed-meshheading:21454292-Male, pubmed-meshheading:21454292-Mice, pubmed-meshheading:21454292-Mice, 129 Strain, pubmed-meshheading:21454292-Mice, Inbred C57BL, pubmed-meshheading:21454292-Period Circadian Proteins, pubmed-meshheading:21454292-Seasons, pubmed-meshheading:21454292-Selection, Genetic, pubmed-meshheading:21454292-Survival
pubmed:year
2011
pubmed:articleTitle
Lab mice in the field: unorthodox daily activity and effects of a dysfunctional circadian clock allele.
pubmed:affiliation
Centre for Life Sciences, University of Groningen, Hoofdweg 274, 9765 CN Paterswolde, The Netherlands. s.daan@rug.nl
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't