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| pubmed-article:2145165 | lifeskim:mentions | umls-concept:C0006556 | lld:lifeskim |
| pubmed-article:2145165 | lifeskim:mentions | umls-concept:C0108779 | lld:lifeskim |
| pubmed-article:2145165 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2145165 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:2145165 | lifeskim:mentions | umls-concept:C0162801 | lld:lifeskim |
| pubmed-article:2145165 | lifeskim:mentions | umls-concept:C0205280 | lld:lifeskim |
| pubmed-article:2145165 | lifeskim:mentions | umls-concept:C1704788 | lld:lifeskim |
| pubmed-article:2145165 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:2145165 | lifeskim:mentions | umls-concept:C1719914 | lld:lifeskim |
| pubmed-article:2145165 | lifeskim:mentions | umls-concept:C2828406 | lld:lifeskim |
| pubmed-article:2145165 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:2145165 | pubmed:dateCreated | 1990-11-2 | lld:pubmed |
| pubmed-article:2145165 | pubmed:abstractText | In order to characterize the CD3 zeta-related protein found in human natural killer (NK) cells and compare it with CD3 zeta expressed in T lymphocytes, the present study was performed. A polyclonal CD3-CD16+NK population displaying a strong non-major histocompatibility complex-restricted cytotoxic activity against the NK target K-562 was isolated and a product corresponding to CD3 zeta amplified using the polymerase chain reaction method. This 0.6-kb product was present in similar amounts in NK cells and T cells. In contrast, a product corresponding to CD3 delta was amplified from T lymphocytes exclusively. Thus, the CD3 zeta product detected in NK cells did not originate from contaminating T cells. DNA sequence analysis of two independent polymerase chain reaction products from the NK cells demonstrates that human NK cells and mature T cells share a CD3 zeta subunit with an identical primary amino acid sequence. The nucleotide sequence of a third NK-derived cDNA revealed an insertion of a CAG triplet encoding an additional glutamine residue in the cytoplasmic domain. Since this residue is encoded by nucleotides at a putative RNA splice junction, it possibly results from a difference in pre-mRNA splicing. Taken together, these data show that CD3 zeta is not structurally distinct in NK cells and in T lymphocytes. | lld:pubmed |
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| pubmed-article:2145165 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2145165 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2145165 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2145165 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2145165 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2145165 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2145165 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:2145165 | pubmed:author | pubmed-author:ReinherzE LEL | lld:pubmed |
| pubmed-article:2145165 | pubmed:author | pubmed-author:D'AdamioLL | lld:pubmed |
| pubmed-article:2145165 | pubmed:author | pubmed-author:MoingeonPP | lld:pubmed |
| pubmed-article:2145165 | pubmed:author | pubmed-author:StebbinsC CCC | lld:pubmed |
| pubmed-article:2145165 | pubmed:author | pubmed-author:LucichJJ | lld:pubmed |
| pubmed-article:2145165 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2145165 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:2145165 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2145165 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2145165 | pubmed:pagination | 1741-5 | lld:pubmed |
| pubmed-article:2145165 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:2145165 | pubmed:meshHeading | pubmed-meshheading:2145165-... | lld:pubmed |
| pubmed-article:2145165 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2145165 | pubmed:articleTitle | Human natural killer cells and mature T lymphocytes express identical CD3 zeta subunits as defined by cDNA cloning and sequence analysis. | lld:pubmed |
| pubmed-article:2145165 | pubmed:affiliation | Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115. | lld:pubmed |
| pubmed-article:2145165 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2145165 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2145165 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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