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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2011-5-30
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pubmed:abstractText |
Uterine leiomyosarcoma generally has an unfavorable response to standard chemotherapy. The loss of PTEN which results in constitutive AKT-mTOR activation causes an increase in leiomyosarcoma formation in mice. The active ingredient derived from the herb Curcuma longa, curcumin, shows antitumor properties in a variety of cancer cell lines by altering a number of oncogenic pathways. To explore the possibility of curcumin as an alternative to standard chemotherapy, we decided to investigate curcumin's antitumor effect on uterine leiomyosarcoma cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1095-6859
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
122
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
141-8
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pubmed:meshHeading |
pubmed-meshheading:21450334-AMP-Activated Protein Kinases,
pubmed-meshheading:21450334-Antineoplastic Agents,
pubmed-meshheading:21450334-Apoptosis,
pubmed-meshheading:21450334-Cell Line, Tumor,
pubmed-meshheading:21450334-Cell Survival,
pubmed-meshheading:21450334-Curcumin,
pubmed-meshheading:21450334-Dose-Response Relationship, Drug,
pubmed-meshheading:21450334-Enzyme Activation,
pubmed-meshheading:21450334-Female,
pubmed-meshheading:21450334-Humans,
pubmed-meshheading:21450334-Leiomyosarcoma,
pubmed-meshheading:21450334-Oncogene Protein v-akt,
pubmed-meshheading:21450334-Signal Transduction,
pubmed-meshheading:21450334-Sirolimus,
pubmed-meshheading:21450334-TOR Serine-Threonine Kinases,
pubmed-meshheading:21450334-Uterine Neoplasms
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pubmed:year |
2011
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pubmed:articleTitle |
Curcumin disrupts uterine leiomyosarcoma cells through AKT-mTOR pathway inhibition.
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pubmed:affiliation |
Department of Obstetrics and Gynecology, Sendai, Japan.
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pubmed:publicationType |
Journal Article
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