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rdf:type |
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lifeskim:mentions |
umls-concept:C0001779,
umls-concept:C0003595,
umls-concept:C0034927,
umls-concept:C0087111,
umls-concept:C0332281,
umls-concept:C0442592,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1882417,
umls-concept:C2911692
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pubmed:dateCreated |
2011-4-19
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pubmed:abstractText |
The risk of coronary heart disease (CHD) is related to environmental factors and genetic variants. Apolipoprotein E (apoE) polymorphisms are heritable determinants of total and low-density lipoprotein cholesterol, with some authors suggesting an association between the ?4 allele and CHD. We investigated the relationship between apoE genotype and age at referral to a specialized lipid clinic by the primary care physician and whether the benefits of treatment with statin differed between genotypes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-10736278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-11060351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-11079660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-11273909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-11302109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-11701639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-11882522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-12028507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-12461692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-12485966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-1357300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-15630634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-16671834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-17172560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-17224309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-17567623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-17878422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-18334912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-1836947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-18656198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-18855536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-1940775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-19667307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-20031582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-20966513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-21059196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-3277611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-3611358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-7605354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-7605379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-7805227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-7848369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-8421977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-9105566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21450082-9591747
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1476-511X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
48
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pubmed:meshHeading |
pubmed-meshheading:21450082-Adult,
pubmed-meshheading:21450082-Apolipoprotein E4,
pubmed-meshheading:21450082-Dyslipidemias,
pubmed-meshheading:21450082-Female,
pubmed-meshheading:21450082-Genotype,
pubmed-meshheading:21450082-Humans,
pubmed-meshheading:21450082-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:21450082-Male,
pubmed-meshheading:21450082-Middle Aged,
pubmed-meshheading:21450082-Polymorphism, Genetic,
pubmed-meshheading:21450082-Risk Factors
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pubmed:year |
2011
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pubmed:articleTitle |
Apolipoprotein E epsilon-4 polymorphism is associated with younger age at referral to a lipidology clinic and a poorer response to lipid-lowering therapy.
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pubmed:affiliation |
Department of Cardiology, Coimbra Hospital and Medical School, Coimbra, Portugal. ruibaptista@gmail.com
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pubmed:publicationType |
Journal Article
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