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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-3-30
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pubmed:abstractText |
Obesity promotes inflammation in adipose tissue (AT) and this is implicated in pathophysiological complications such as insulin resistance, type 2 diabetes and cardiovascular disease. Although based on the classical hypothesis, necrotic AT adipocytes (ATA) in obese state activate AT macrophages (ATM) that then lead to a sustained chronic inflammation in AT, the link between human adipocytes and the source of inflammation in AT has not been in-depth and systematically studied. So we decided as a new hypothesis to investigate human primary adipocytes alone to see whether they are able to prime inflammation in AT.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21448265-10837054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21448265-11027337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21448265-11244051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21448265-11371650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21448265-11524386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21448265-12432042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21448265-13872177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21448265-14530283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21448265-14679172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21448265-14679176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21448265-15576462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21448265-1568535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21448265-15710187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21448265-15731108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21448265-15864338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21448265-15941925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21448265-16419016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21448265-16448533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21448265-16731815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21448265-16823477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21448265-17316300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21448265-17409382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21448265-17931767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21448265-8665672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21448265-9796811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21448265-9971870
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
pubmed-author:Al-LahhamSaadS,
pubmed-author:BruinenbergMarcelM,
pubmed-author:DijkstraMartijnM,
pubmed-author:KloosterhuisNielsN,
pubmed-author:KroesenBart-JanBJ,
pubmed-author:MeijerKeesK,
pubmed-author:RezaeeFarhadF,
pubmed-author:VonkRoelR,
pubmed-author:WeeningDesiréeD,
pubmed-author:de VriesMarcelM,
pubmed-author:van der LeijRoelof JanRJ,
pubmed-author:van der WantHanH
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e17154
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pubmed:dateRevised |
2011-7-27
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pubmed:meshHeading |
pubmed-meshheading:21448265-Acute-Phase Proteins,
pubmed-meshheading:21448265-Adipocytes,
pubmed-meshheading:21448265-Biological Markers,
pubmed-meshheading:21448265-CD4-Positive T-Lymphocytes,
pubmed-meshheading:21448265-Cell Differentiation,
pubmed-meshheading:21448265-Cell Movement,
pubmed-meshheading:21448265-Cells, Cultured,
pubmed-meshheading:21448265-Chemokines,
pubmed-meshheading:21448265-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:21448265-Gene Expression Regulation,
pubmed-meshheading:21448265-Histocompatibility Antigens Class II,
pubmed-meshheading:21448265-Humans,
pubmed-meshheading:21448265-Inflammation,
pubmed-meshheading:21448265-Lymphocyte Activation,
pubmed-meshheading:21448265-Macrophages,
pubmed-meshheading:21448265-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:21448265-Proteomics,
pubmed-meshheading:21448265-Receptors, Chemokine
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pubmed:year |
2011
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pubmed:articleTitle |
Human primary adipocytes exhibit immune cell function: adipocytes prime inflammation independent of macrophages.
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pubmed:affiliation |
Center for Medical Biomics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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